Vesicle-associated membrane protein

Synaptobrevin
Three different views of the high resolution structure of a truncated neuronal SNARE complex. Legend: synaptobrevin-2 (red), Syntaxin-1 (pink), SNAP-25 (purple).
Identifiers
Symbol Synaptobrevin
Pfam PF00957
InterPro IPR016444
PROSITE PDOC00368
SCOP 1sfc
SUPERFAMILY 1sfc
OPM superfamily 197
OPM protein 4wy4
Membranome 198

Vesicle associated membrane proteins (VAMP) are a family of SNARE proteins with similar structure, and are mostly involved in vesicle fusion.

  • VAMP1 and VAMP2 proteins known as synaptobrevins are expressed in brain and are constituents of the synaptic vesicles, where they participate in neuromediator release.
  • VAMP3 (known as cellubrevin) is ubiquitously expressed and participates in regulated and constitutive exocytosis as a constituent of secretory granules and secretory vesicles.
  • VAMP5 and VAMP7 (SYBL1) participate in constitutive exocytosis.
    • VAMP5 is a constituent of secretory vesicles, myotubes and tubulovesicular structures.
    • VAMP7 is found both in secretory granules and endosomes.
  • VAMP8 (known as endobrevin) participates in endocytosis and is found in early endosomes. VAMP8 also participates the regulated exocytosis in pancreatic acinar cells.
  • VAMP4 is involved in transport from the Golgi.[1]

References

  1. ↑ Steegmaier M, Klumperman J, Foletti DL, Yoo JS, Scheller RH (1999). "Vesicle-associated membrane protein 4 is implicated in trans-Golgi network vesicle trafficking". Mol. Biol. Cell. 10 (6): 1957–72. doi:10.1091/mbc.10.6.1957. PMC 25394. PMID 10359608.


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