Triethylcholine

Triethylcholine

Clinical data
ATC code	None
Identifiers
IUPAC name N,N,N-triethyl-2-hydroxyethanaminium
CAS Number	302-61-4 N
PubChem CID	80058
IUPHAR/BPS	4760
ChemSpider	72310 N
Chemical and physical data
Formula	C8H20NO
Molar mass	146.2505 g/mol
3D model (JSmol)	Interactive image
SMILES CC[N+](CC)(CC)CCO
InChI InChI=1S/C11H26NO/c1-7-10(12(4,5)6)11(13,8-2)9-3/h10,13H,7-9H2,1-6H3/q+1 Y Key:FWWCPIVPYLRCPR-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Triethylcholine is a drug which mimics choline, and causes failure of cholinergic transmission by interfering with synthesis of acetylcholine in nerve endings.^[1]

Effects

Triethylcholine produces a slowly developing neuromuscular weakness that is exacerbated by exercise, resembling the symptoms of myasthenia gravis. It also has ganglionic blocking effects, causing transient autonomic symptoms such as hypotension. Muscles stimulated at a high contraction rate are much more affected than those stimulated at a low rate. The muscle weakness typically lasts for 80 to 120 minutes; it is partially relieved by rest. High doses may result in death from respiratory failure, particularly after exercise. Triethylcholine seems to interfere with the synthesis of acetylcholine in the presynaptic nerve endings, since its effects are reversed by choline but not by acetylcholinesterase inhibitors. However the mechanism of action is not definitely known. Animal experiments revealed a relatively low acute toxicity: intravenous administration of 10-25 mg/kg triethylcholine iodide produced slight to moderate exercise intolerance, while 100 mg/kg caused death in rabbits after continuous exercise. However there was no full paralysis even at fatal doses. ^[2]

See also

• Hemicholinium-3
• Tetraethylammonium

References