SYT4

SYT4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UGK
Identifiers
Aliases	SYT4, HsT1192, synaptotagmin 4
External IDs	MGI: 101759 HomoloGene: 7559 GeneCards: SYT4
Gene location (Human)
Chr.	Chromosome 18 (human)[1]
End	43,277,650 bp[1]
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)[2]
End	31,447,415 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• calcium ion binding; • clathrin binding; • phosphatidylserine binding; • metal ion binding; • protein binding; • SNARE binding; • syntaxin-1 binding; • syntaxin binding; • syntaxin-3 binding; • protein homodimerization activity; • protein heterodimerization activity; • calcium-dependent phospholipid binding;
Cellular component	• integral component of membrane; • intracellular membrane-bounded organelle; • membrane; • synapse; • synaptic vesicle membrane; • cell junction; • perinuclear region of cytoplasm; • neuron projection; • dense core granule; • cytoplasmic vesicle; • dendrite; • Golgi apparatus; • vesicle; • axon; • plasma membrane; • synaptic vesicle; • integral component of Golgi membrane; • integral component of synaptic vesicle membrane; • secretory granule membrane; • dense core granule membrane; • somatodendritic compartment; • neuronal cell body; • neuron projection terminus; • exocytic vesicle; • astrocyte projection; • microvesicle; • glutamatergic synapse; • integral component of neuronal dense core vesicle membrane;
Biological process	• cell differentiation; • brain development; • positive regulation of dendrite extension; • negative regulation of vesicle fusion; • neurotransmitter secretion; • exocytosis; • vesicle fusion; • calcium ion-regulated exocytosis of neurotransmitter; • memory; • positive regulation of glutamate secretion; • regulation of dopamine secretion; • regulation of endocytosis; • regulation of vesicle fusion; • negative regulation of catecholamine secretion; • positive regulation of calcium ion-dependent exocytosis; • negative regulation of neurotransmitter secretion; • negative regulation of short-term neuronal synaptic plasticity; • vesicle fusion with vesicle; • secretory granule maturation; • negative regulation of protein secretion; • negative regulation of retrograde trans-synaptic signaling by neuropeptide; • regulation of calcium ion-dependent exocytosis; • negative regulation of calcium ion-dependent exocytosis; • trans-synaptic signaling by BDNF, modulating synaptic transmission; • vesicle-mediated transport; • calcium ion regulated exocytosis; • cellular response to calcium ion; • regulation of presynaptic dense core granule exocytosis; • negative regulation of dense core granule exocytosis; • positive regulation of dense core granule exocytosis; • negative regulation of synaptic vesicle exocytosis;
	Sources:Amigo / QuickGO
Orthologs
	6860
	20983
	ENSG00000132872
	ENSMUSG00000024261
	Q9H2B2
	P40749
	NM_020783
	NM_009308
	NP_065834
	NP_033334
	Wikidata
View/Edit Human	View/Edit Mouse

Synaptotagmin-4 is a protein that in humans is encoded by the SYT4 gene.^[5]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000132872 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024261 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Hilbush BS, Morgan JI (Sep 1994). "A third synaptotagmin gene, Syt3, in the mouse". Proc Natl Acad Sci U S A. 91 (17): 8195–9. doi:10.1073/pnas.91.17.8195. PMC 44572. PMID 8058779.
↑ "Entrez Gene: SYT4 synaptotagmin IV".

Ullrich B, Li C, Zhang JZ, et al. (1995). "Functional properties of multiple synaptotagmins in brain". Neuron. 13 (6): 1281–91. doi:10.1016/0896-6273(94)90415-4. PMID 7993622.
Perin MS (1996). "Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin". Biochemistry. 35 (43): 13808–16. doi:10.1021/bi960853x. PMID 8901523.
Thomas DM, Ferguson GD, Herschman HR, Elferink LA (1999). "Functional and biochemical analysis of the C2 domains of synaptotagmin IV". Mol. Biol. Cell. 10 (7): 2285–95. doi:10.1091/mbc.10.7.2285. PMC 25443. PMID 10397765.
Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
Mizutani A, Fukuda M, Ibata K, et al. (2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". J. Biol. Chem. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.
Ferguson GD, Chen XN, Korenberg JR, Herschman HR (2001). "The human synaptotagmin IV gene defines an evolutionary break point between syntenic mouse and human chromosome regions but retains ligand inducibility and tissue specificity". J. Biol. Chem. 275 (47): 36920–6. doi:10.1074/jbc.M005801200. PMID 10938284.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000132872 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024261 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid8058779-5] Hilbush BS, Morgan JI (Sep 1994). "A third synaptotagmin gene, Syt3, in the mouse". Proc Natl Acad Sci U S A. 91 (17): 8195–9. doi:10.1073/pnas.91.17.8195. PMC 44572. PMID 8058779.

[entrez-6] "Entrez Gene: SYT4 synaptotagmin IV".

SYT4

References

Further reading