Licarbazepine

Licarbazepine
Top: (R)-(−)-licarbazepine
Bottom: (S)-(+)-licarbazepine
Clinical data
ATC code
  • None
Pharmacokinetic data
Protein binding <40%
Metabolites Glucuronides
Excretion Mainly renal
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
ECHA InfoCard 100.122.427 Edit this at Wikidata
Chemical and physical data
Formula C15H14N2O2
Molar mass 254.28 g/mol
3D model (JSmol)
Chirality Racemic mixture

Licarbazepine is a voltage-gated sodium channel blocker with anticonvulsant and mood-stabilizing effects that is related to oxcarbazepine.[1] It is an active metabolite of oxcarbazepine.[1][2] In addition, an isomer of licarbazepine, eslicarbazepine ((S)-(+)-licarbazepine), is an active metabolite of eslicarbazepine acetate.[1][2] Oxcarbazepine and eslicarbazepine acetate are inactive on their own, and behave instead as prodrugs to licarbazepine and eslicarbazepine, respectively, to produce their therapeutic effects.[1][2]

References

  1. 1 2 3 4 Singh RP, Asconapé JJ (2011). "A review of eslicarbazepine acetate for the adjunctive treatment of partial-onset epilepsy". J Cent Nerv Syst Dis. 3: 179–87. doi:10.4137/JCNSD.S4888. PMC 3663619. PMID 23861647.
  2. 1 2 3 Bialer M, Soares-da-Silva P (June 2012). "Pharmacokinetics and drug interactions of eslicarbazepine acetate". Epilepsia. 53 (6): 935–46. doi:10.1111/j.1528-1167.2012.03519.x. PMID 22612290.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.