CD247

CD247
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCD247, CD3-ZETA, CD3H, CD3Q, CD3Z, IMD25, T3Z, TCRZ, CD247 molecule
External IDsMGI: 88334 HomoloGene: 12818 GeneCards: CD247
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q24.2Start167,430,640 bp[1]
End167,518,610 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

919

12503

Ensembl

ENSG00000198821

ENSMUSG00000005763

UniProt

P20963

P29020
P24161

RefSeq (mRNA)

NM_000734
NM_198053

NM_001113391
NM_001113392
NM_001113393
NM_001113394
NM_031162

RefSeq (protein)

NP_000725
NP_932170

Location (UCSC)Chr 1: 167.43 – 167.52 MbChr 1: 165.79 – 165.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

T-cell surface glycoprotein CD3 zeta chain also known as T-cell receptor T3 zeta chain or CD247 (Cluster of Differentiation 247) is a protein that in humans is encoded by the CD247 gene.[5]

Genomics

The gene is located on the long arm of chromosome 1 at location 1q22-q25 on the Crick (negative) strand. The gene is 87,896 bases in length. The encoded protein is 164 amino acids long with a predicted weight of 18.696 kiloDaltons.

Function

T-cell receptor zeta (ζ), together with T-cell receptor alpha/beta and gamma/delta heterodimers and CD3-gamma, -delta, and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[6]

Interactions

CD247 has been shown to interact with Janus kinase 3[7] and Protein unc-119 homolog.[8]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000198821 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005763 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Weissman AM, Hou D, Orloff DG, Modi WS, Seuanez H, O'Brien SJ, Klausner RD (December 1988). "Molecular cloning and chromosomal localization of the human T-cell receptor zeta chain: distinction from the molecular CD3 complex". Proc. Natl. Acad. Sci. U.S.A. 85 (24): 9709–13. doi:10.1073/pnas.85.24.9709. PMC 282845. PMID 2974162.
  6. ↑ "Entrez Gene: CD247 CD247 molecule".
  7. ↑ Tomita K, Saijo K, Yamasaki S, Iida T, Nakatsu F, Arase H, Ohno H, Shirasawa T, Kuriyama T, O'Shea JJ, Saito T (Jul 2001). "Cytokine-independent Jak3 activation upon T cell receptor (TCR) stimulation through direct association of Jak3 and the TCR complex". J. Biol. Chem. 276 (27): 25378–85. doi:10.1074/jbc.M011363200. PMID 11349123.
  8. ↑ Gorska MM, Stafford SJ, Cen O, Sur S, Alam R (Feb 2004). "Unc119, a novel activator of Lck/Fyn, is essential for T cell activation". J. Exp. Med. 199 (3): 369–79. doi:10.1084/jem.20030589. PMC 2211793. PMID 14757743.

Further reading

  • Geyer M, Fackler OT, Peterlin BM (2001). "Structure--function relationships in HIV-1 Nef". EMBO Rep. 2 (7): 580–5. doi:10.1093/embo-reports/kve141. PMC 1083955. PMID 11463741.
  • Greenway AL, Holloway G, McPhee DA, Ellis P, Cornall A, Lidman M (2004). "HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication". J. Biosci. 28 (3): 323–35. doi:10.1007/BF02970151. PMID 12734410.
  • Stove V, Verhasselt B (2006). "Modelling thymic HIV-1 Nef effects". Curr. HIV Res. 4 (1): 57–64. doi:10.2174/157016206775197583. PMID 16454711.


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