NCR3

NCR3
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesNCR3, 1C7, CD337, LY117, MALS, NKp30, natural cytotoxicity triggering receptor 3
External IDsHomoloGene: 51827 GeneCards: NCR3
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6p21.33Start31,588,895 bp[1]
End31,592,985 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

259197

n/a

Ensembl

n/a

UniProt

O14931

n/a

RefSeq (mRNA)

NM_001145466
NM_001145467
NM_147130

n/a

RefSeq (protein)

NP_001138938
NP_001138939
NP_667341

n/a

Location (UCSC)Chr 6: 31.59 – 31.59 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Natural cytotoxicity triggering receptor 3 is a protein that in humans is encoded by the NCR3 gene.[3][4][5] NCR3 has also been designated as CD337 (cluster of differentiation 337) and as NKp30.

References

  1. 1 2 3 ENSG00000236979, ENSG00000206430, ENSG00000237808, ENSG00000236315, ENSG00000223833, ENSG00000225211, ENSG00000204475 GRCh38: Ensembl release 89: ENSG00000237103, ENSG00000236979, ENSG00000206430, ENSG00000237808, ENSG00000236315, ENSG00000223833, ENSG00000225211, ENSG00000204475 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:".
  3. ↑ Nalabolu SR, Shukla H, Nallur G, Parimoo S, Weissman SM (Mar 1997). "Genes in a 220-kb region spanning the TNF cluster in human MHC". Genomics. 31 (2): 215–22. doi:10.1006/geno.1996.0034. PMID 8824804.
  4. ↑ Sato M, Ohashi J, Tsuchiya N, Tadokoro K, Juji T, Hanaoka K, Tokunaga K, Yabe T (Jan 2002). "Identification of novel single nucleotide substitutions in the NKp30 gene expressed in human natural killer cells". Tissue Antigens. 58 (4): 255–8. doi:10.1034/j.1399-0039.2001.580406.x. PMID 11782277.
  5. ↑ "Entrez Gene: NCR3 natural cytotoxicity triggering receptor 3".

Further reading

  • Djeu JY, Jiang K, Wei S (2002). "A view to a kill: signals triggering cytotoxicity". Clin. Cancer Res. 8 (3): 636–40. PMID 11895890.
  • Holzinger I, de Baey A, Messer G, et al. (1995). "Cloning and genomic characterization of LST1: a new gene in the human TNF region". Immunogenetics. 42 (5): 315–22. doi:10.1007/BF00179392. PMID 7590964.
  • de Baey A, Fellerhoff B, Maier S, et al. (1998). "Complex expression pattern of the TNF region gene LST1 through differential regulation, initiation, and alternative splicing". Genomics. 45 (3): 591–600. doi:10.1006/geno.1997.4963. PMID 9367684.
  • Neville MJ, Campbell RD (1999). "A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC". J. Immunol. 162 (8): 4745–54. PMID 10202016.
  • Pende D, Parolini S, Pessino A, et al. (1999). "Identification and Molecular Characterization of Nkp30, a Novel Triggering Receptor Involved in Natural Cytotoxicity Mediated by Human Natural Killer Cells". J. Exp. Med. 190 (10): 1505–16. doi:10.1084/jem.190.10.1505. PMC 2195691. PMID 10562324.
  • Sivakamasundari R, Raghunathan A, Zhang CY, et al. (2000). "Expression and cellular localization of the protein encoded by the 1C7 gene: a recently described component of the MHC". Immunogenetics. 51 (8–9): 723–32. doi:10.1007/s002510000192. PMID 10941844.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Le Bouteiller P, Barakonyi A, Giustiniani J, et al. (2003). "Engagement of CD160 receptor by HLA-C is a triggering mechanism used by circulating natural killer (NK) cells to mediate cytotoxicity". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16963–8. doi:10.1073/pnas.012681099. PMC 139252. PMID 12486241.
  • Augugliaro R, Parolini S, Castriconi R, et al. (2003). "Selective cross-talk among natural cytotoxicity receptors in human natural killer cells". Eur. J. Immunol. 33 (5): 1235–41. doi:10.1002/eji.200323896. PMID 12731048.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
  • Marcenaro E, Augugliaro R, Falco M, et al. (2004). "CD59 is physically and functionally associated with natural cytotoxicity receptors and activates human NK cell-mediated cytotoxicity". Eur. J. Immunol. 33 (12): 3367–76. doi:10.1002/eji.200324425. PMID 14635045.
  • Xie T, Rowen L, Aguado B, et al. (2004). "Analysis of the Gene-Dense Major Histocompatibility Complex Class III Region and Its Comparison to Mouse". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC 403804. PMID 14656967.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Nowbakht P, Ionescu MC, Rohner A, et al. (2005). "Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias". Blood. 105 (9): 3615–22. doi:10.1182/blood-2004-07-2585. PMID 15657183.
  • Poggi A, Massaro AM, Negrini S, et al. (2005). "Tumor-induced apoptosis of human IL-2-activated NK cells: role of natural cytotoxicity receptors". J. Immunol. 174 (5): 2653–60. doi:10.4049/jimmunol.174.5.2653. PMID 15728472.
  • Vitale M, Della Chiesa M, Carlomagno S, et al. (2005). "NK-dependent DC maturation is mediated by TNFalpha and IFNgamma released upon engagement of the NKp30 triggering receptor". Blood. 106 (2): 566–71. doi:10.1182/blood-2004-10-4035. PMID 15784725.
  • Warren HS, Jones AL, Freeman C, et al. (2005). "Evidence that the cellular ligand for the human NK cell activation receptor NKp30 is not a heparan sulfate glycosaminoglycan". J. Immunol. 175 (1): 207–12. doi:10.4049/jimmunol.175.1.207. PMID 15972650.
  • Joyce MG, Gordon M, Tran P, et al. (2011). "Crystal structure of human natural cytotoxicity receptor NKp30 and identification of its ligand binding site". PNAS. 108 (15): 6223–6228. doi:10.1073/pnas.1100622108. PMC 3076882. PMID 21444796.

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