Cloniprazepam
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| Synonyms | 1-Cyclopropylmethylclonazepam, Kloniprazepam, 2-Chloro-7'-nitroprazepam |
| Drug class | Benzodiazepines |
| Legal status | |
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| Identifiers | |
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| Chemical and physical data | |
| Formula | C19H16ClN3O3 |
| Molar mass | 369.802 g/mol |
| 3D model (JSmol) | |
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Metabolic pathway of cloniprazepam
Cloniprazepam is a benzodiazepine derivative and a prodrug mainly for clonazepam (a patented medicine) and other metabolites.,[1][2] including 7-aminoclonazepam and clonazepam mentioned above (both as metabolites), which may be misinterpreted as clonazepam intake at the result of a drug test.[1]
Some of the minor metabolites include 3-hydroxy and 6-hydroxyclonazepam, 3-hydroxycloniprazepam and ketocloniprazepam with ketone group formed where 3-hydroxy group was.[1]
It is a designer drug and an NPS (short for "new psychoactive substance").[1] At the end of 2017, cloniprazepam remains an uncontrolled substance in most of the countries.
See also
References
- 1 2 3 4 Moosmann, Bjoern; Bisel, Philippe; Franz, Florian; Huppertz, Laura M.; Auwärter, Volker (November 2016). "Characterization and in vitro phase I microsomal metabolism of designer benzodiazepines — an update comprising adinazolam, cloniprazepam, fonazepam, 3-hydroxyphenazepam, metizolam and nitrazolam". Journal of Mass Spectrometry. 51 (11): 1080–1089. doi:10.1002/jms.3840. ISSN 1096-9888. PMID 27535017.
- ↑ "In vitro Phase I and Phase II metabolism of the new designer benzodiazepine cloniprazepam using liquid chromatography coupled to quadrupole time-of-flight mass spectrometry". Journal of Pharmaceutical and Biomedical Analysis. 2018. doi:10.1016/j.jpba.2018.02.032. ISSN 0731-7085. PMID 29494888.
External links
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