PDCD1LG2

PDCD1LG2
Identifiers
AliasesPDCD1LG2, B7DC, Btdc, CD273, PD-L2, PDCD1L2, PDL2, bA574F11.2, programmed cell death 1 ligand 2
External IDsMGI: 1930125 HomoloGene: 10973 GeneCards: PDCD1LG2
Gene location (Human)
Chr.Chromosome 9 (human)[1]
Band9p24.1Start5,510,570 bp[1]
End5,571,254 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

80380

58205

Ensembl

ENSG00000197646

ENSMUSG00000016498

UniProt

Q9BQ51

Q9WUL5

RefSeq (mRNA)

NM_025239

NM_021396

RefSeq (protein)

NP_079515

NP_067371

Location (UCSC)Chr 9: 5.51 – 5.57 MbChr 19: 29.41 – 29.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Programmed cell death 1 ligand 2 (also known as PD-L2, B7-DC) is a protein that in humans is encoded by the PDCD1LG2 gene.[5][6] PDCD1LG2 has also been designated as CD273 (cluster of differentiation 273).

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000197646 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000016498 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Latchman Y, Wood CR, Chernova T, Chaudhary D, Borde M, Chernova I, Iwai Y, Long AJ, Brown JA, Nunes R, Greenfield EA, Bourque K, Boussiotis VA, Carter LL, Carreno BM, Malenkovich N, Nishimura H, Okazaki T, Honjo T, Sharpe AH, Freeman GJ (Mar 2001). "PD-L2 is a second ligand for PD-1 and inhibits T cell activation". Nat Immunol. 2 (3): 261–8. doi:10.1038/85330. PMID 11224527.
  6. ↑ "Entrez Gene: PDCD1LG2 programmed cell death 1 ligand 2".

Further reading

  • Tseng SY, Otsuji M, Gorski K, et al. (2001). "B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells". J. Exp. Med. 193 (7): 839–46. doi:10.1084/jem.193.7.839. PMC 2193370. PMID 11283156.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Brown JA, Dorfman DM, Ma FR, et al. (2003). "Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production". J. Immunol. 170 (3): 1257–66. doi:10.4049/jimmunol.170.3.1257. PMID 12538684.
  • Youngnak P, Kozono Y, Kozono H, et al. (2003). "Differential binding properties of B7-H1 and B7-DC to programmed death-1". Biochem. Biophys. Res. Commun. 307 (3): 672–7. doi:10.1016/S0006-291X(03)01257-9. PMID 12893276.
  • Tsushima F, Iwai H, Otsuki N, et al. (2003). "Preferential contribution of B7-H1 to programmed death-1-mediated regulation of hapten-specific allergic inflammatory responses". Eur. J. Immunol. 33 (10): 2773–82. doi:10.1002/eji.200324084. PMID 14515261.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Aramaki O, Shirasugi N, Takayama T, et al. (2004). "Programmed death-1-programmed death-L1 interaction is essential for induction of regulatory cells by intratracheal delivery of alloantigen". Transplantation. 77 (1): 6–12. doi:10.1097/01.TP.0000108637.65091.4B. PMID 14724428.
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
  • He XH, Liu Y, Xu LH, Zeng YY (2004). "Cloning and identification of two novel splice variants of human PD-L2". Acta Biochim. Biophys. Sin. (Shanghai). 36 (4): 284–9. doi:10.1093/abbs/36.4.284. PMID 15253154.
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ohigashi Y, Sho M, Yamada Y, et al. (2005). "Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer". Clin. Cancer Res. 11 (8): 2947–53. doi:10.1158/1078-0432.CCR-04-1469. PMID 15837746.
  • Saunders PA, Hendrycks VR, Lidinsky WA, Woods ML (2006). "PD-L2:PD-1 involvement in T cell proliferation, cytokine production, and integrin-mediated adhesion". Eur. J. Immunol. 35 (12): 3561–9. doi:10.1002/eji.200526347. PMID 16278812.
  • Pfistershammer K, Klauser C, Pickl WF, et al. (2006). "No evidence for dualism in function and receptors: PD-L2/B7-DC is an inhibitory regulator of human T cell activation". Eur. J. Immunol. 36 (5): 1104–13. doi:10.1002/eji.200535344. PMC 2975063. PMID 16598819.
  • Abelson AK, Johansson CM, Kozyrev SV, et al. (2007). "No evidence of association between genetic variants of the PDCD1 ligands and SLE". Genes Immun. 8 (1): 69–74. doi:10.1038/sj.gene.6364360. PMID 17136123.
  • Mataki N, Kikuchi K, Kawai T, et al. (2007). "Expression of PD-1, PD-L1, and PD-L2 in the liver in autoimmune liver diseases". Am. J. Gastroenterol. 102 (2): 302–12. doi:10.1111/j.1572-0241.2006.00948.x. PMID 17311651.
  • Wang SC, Lin CH, Ou TT, et al. (2007). "Ligands for programmed cell death 1 gene in patients with systemic lupus erythematosus". J. Rheumatol. 34 (4): 721–5. doi:10.1093/rheumatology/34.8.721. PMID 17343323.
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