Binedaline

Binedaline
Clinical data
Routes of
administration		 Oral
ATC code
  • None
Legal status
Legal status
  • In general: unscheduled
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
Formula C19H23N3
Molar mass 293.41 g·mol−1
3D model (JSmol)
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Binedaline (also called binodaline; trade name Ixprim) is a drug that was investigated as an antidepressant in the 1980s but was never marketed.[1][2] It acts as a selective norepinephrine reuptake inhibitor (Ki = 25 nM), with relatively insignificant influence on the serotonin (Ki = 847 nM) and dopamine (Ki >= 2 µM) transporters.[3] It has negligible affinity for the α-adrenergic, mACh, H1, or 5-HT2 receptors.[3]

References

  1. ↑ Faltus; Geerling, F. (1984). "A controlled double-blind study comparing binedaline and imipramine in the treatment of endogenous depression". Neuropsychobiology. 12 (1): 34–38. doi:10.1159/000118107. PMID 6239991.
  2. ↑ David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9.
  3. 1 2 Morin; Zini, R.; Urien, S.; Tillement, J. P. (1989). "Pharmacological profile of binedaline, a new antidepressant drug". The Journal of Pharmacology and Experimental Therapeutics. 249 (1): 288–296. PMID 2540319.

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