Butaxamine

Butaxamine
Clinical data
ATC code	None;
Identifiers
	IUPAC name (1S,2S)-1-(2,5-dimethoxyphenyl)-2-; (tert-butylamino)propan-1-ol;
CAS Number	2922-20-5 ;
PubChem CID	21909;
ChemSpider	20593 ;
UNII	0NM31M53PW;
ChEMBL	CHEMBL289093;
Chemical and physical data
Formula	C15H25NO3
Molar mass	267.364 g/mol
3D model (JSmol)	Interactive image;
	SMILES Cl.O(c1ccc(OC)cc1C(O)C(NC(C)(C)C)C)C;
	InChI InChI=1S/C15H25NO3.ClH/c1-10(16-15(2,3)4)14(17)12-9-11(18-5)7-8-13(12)19-6;/h7-10,14,16-17H,1-6H3;1H ; Key:URPAECSKKQLCII-UHFFFAOYSA-N ;
(verify)

Butaxamine (INN, also known as butoxamine) is a β₂-selective beta blocker.^[1]^[2] Its primary use is in experimental situations in which blockade of β₂ receptors is necessary to determine the activity of the drug (i.e. if the β₂ receptor is completely blocked, but the given effect is still present, the given effect is not a characteristic of the β₂ receptor). It has no clinical use. An alternative name is α-(1-[tert-butylamino]ethyl)-2,5-dimethoxybenzyl alcohol.

References

↑ "Definition: butoxamine from Online Medical Dictionary".
↑ Hillman KL, Doze VA, Porter JE (August 2005). "Functional characterization of the beta-adrenergic receptor subtypes expressed by CA1 pyramidal cells in the rat hippocampus". J. Pharmacol. Exp. Ther. 314 (2): 561–7. doi:10.1124/jpet.105.084947. PMID 15908513.

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[urlDefinition:_butoxamine_from_Online_Medical_Dictionary-1] "Definition: butoxamine from Online Medical Dictionary".

[pmid15908513-2] Hillman KL, Doze VA, Porter JE (August 2005). "Functional characterization of the beta-adrenergic receptor subtypes expressed by CA1 pyramidal cells in the rat hippocampus". J. Pharmacol. Exp. Ther. 314 (2): 561–7. doi:10.1124/jpet.105.084947. PMID 15908513.

Beta blockers (C07)
β, non-selective	Alprenolol Bopindolol Bupranolol Carteolol Cloranolol Mepindolol Nadolol Oxprenolol Penbutolol Pindolol/Iodopindolol Propranolol Sotalol Tertatolol Timolol
β₁-selective	Acebutolol Atenolol Betaxolol Bevantolol Bisoprolol Celiprolol Epanolol Esmolol Landiolol Metoprolol Nebivolol Practolol S-Atenolol Talinolol
β₂-selective	Butaxamine
α₁- + β-selective	Arotinolol Carvedilol Labetalol
^#WHO-EM ^‡Withdrawn from market Clinical trials: ^†Phase III ^§Never to phase III

Clinical data

ATC code	None
Identifiers
IUPAC name (1S,2S)-1-(2,5-dimethoxyphenyl)-2- (tert-butylamino)propan-1-ol
CAS Number	2922-20-5^Y
PubChem CID	21909
ChemSpider	20593^Y
UNII	0NM31M53PW
ChEMBL	CHEMBL289093
Chemical and physical data
Formula	C₁₅H₂₅NO₃
Molar mass	267.364 g/mol
3D model (JSmol)	Interactive image
SMILES Cl.O(c1ccc(OC)cc1C(O)C(NC(C)(C)C)C)C
InChI InChI=1S/C15H25NO3.ClH/c1-10(16-15(2,3)4)14(17)12-9-11(18-5)7-8-13(12)19-6;/h7-10,14,16-17H,1-6H3;1H^Y Key:URPAECSKKQLCII-UHFFFAOYSA-N^Y
(verify)

Butaxamine

See also

References