RPLP0

RPLP0
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4V6X, 5AJ0, 3J92, 4V5Z,%%s4V5Z, 5AJ0, 4V6X, 3J92
Identifiers
Aliases	RPLP0, L10E, LP0, P0, PRLP0, RPP0, ribosomal protein lateral stalk subunit P0
External IDs	OMIM: 180510 MGI: 1927636 HomoloGene: 6517 GeneCards: RPLP0
Gene location (Human)
Chr.	Chromosome 12 (human)[1]
End	120,201,235 bp[1]
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)[2]
End	115,563,727 bp[2]
RNA expression pattern
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	• GO:0001948 protein binding; • structural constituent of ribosome; • RNA binding; • large ribosomal subunit rRNA binding; • peptide binding;
Cellular component	• ribosome; • focal adhesion; • intracellular; • cytoplasmic ribonucleoprotein granule; • cytosolic large ribosomal subunit; • extracellular exosome; • cytoplasm; • cell nucleus; • endoplasmic reticulum; • cytosol; • membrane; • postsynaptic density; • postsynapse; • ribonucleoprotein; • dendrite; • synapse;
Biological process	• ribosome biogenesis; • viral transcription; • SRP-dependent cotranslational protein targeting to membrane; • translational initiation; • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; • protein biosynthesis; • rRNA processing; • viral process; • interleukin-12-mediated signaling pathway; • ribosomal large subunit assembly; • cytoplasmic translation; • lactation; • response to selenium ion; • cellular response to cAMP; • cellular response to interleukin-4; • cellular response to Thyroid stimulating hormone; • cellular response to phorbol 13-acetate 12-myristate;
	Sources:Amigo / QuickGO
Orthologs
	6175
	11837
	ENSG00000089157
	ENSMUSG00000067274
	P05388
	P14869
	NM_053275; NM_001002
	NM_007475
	NP_000993; NP_444505; NP_000993.1; NP_444505.1
	NP_031501
	Wikidata
View/Edit Human	View/Edit Mouse

60S acidic ribosomal protein P0 is a protein that in humans is encoded by the RPLP0 gene.[5][6]

Ribosomes catalyze protein synthesis and consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which is the functional equivalent of the E. coli L10 ribosomal protein, belongs to the L10P family of ribosomal proteins. It is a neutral phosphoprotein with a C-terminal end that is nearly identical to the C-terminal ends of the acidic ribosomal phosphoproteins P1 and P2. The P0 protein can interact with P1 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Transcript variants derived from alternative splicing exist; they encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[6]

References

GRCh38: Ensembl release 89: ENSG00000089157 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000067274 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
"Entrez Gene: RPLP0 ribosomal protein, large, P0".

Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
Rich BE, Steitz JA (1988). "Human acidic ribosomal phosphoproteins P0, P1, and P2: analysis of cDNA clones, in vitro synthesis, and assembly". Mol. Cell. Biol. 7 (11): 4065–74. doi:10.1128/mcb.7.11.4065. PMC 368077. PMID 3323886.
Towbin H, Ramjoué HP, Kuster H, et al. (1982). "Monoclonal antibodies against eucaryotic ribosomes. Use to characterize a ribosomal protein not previously identified and antigenically related to the acidic phosphoproteins P1/P2". J. Biol. Chem. 257 (21): 12709–15. PMID 6182142.
Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
<Please add first missing authors to populate metadata.> (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Tchórzewski M, Boldyreff B, Issinger O, Grankowski N (2000). "Analysis of the protein-protein interactions between the human acidic ribosomal P-proteins: evaluation by the two hybrid system". Int. J. Biochem. Cell Biol. 32 (7): 737–46. doi:10.1016/S1357-2725(00)00017-0. PMID 10856704.
Chan SH, Hung FS, Chan DS, Shaw PC (2001). "Trichosanthin interacts with acidic ribosomal proteins P0 and P1 and mitotic checkpoint protein MAD2B". Eur. J. Biochem. 268 (7): 2107–12. doi:10.1046/j.1432-1327.2001.02091.x. PMID 11277934.
Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders". Genomics. 72 (3): 223–30. doi:10.1006/geno.2000.6470. PMID 11401437.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Tchórzewski M, Krokowski D, Rzeski W, et al. (2003). "The subcellular distribution of the human ribosomal "stalk" components: P1, P2 and P0 proteins". Int. J. Biochem. Cell Biol. 35 (2): 203–11. doi:10.1016/S1357-2725(02)00133-4. PMID 12479870.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Shu H, Chen S, Bi Q, et al. (2004). "Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line". Mol. Cell. Proteomics. 3 (3): 279–86. doi:10.1074/mcp.D300003-MCP200. PMID 14729942.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
Villacé P, Marión RM, Ortín J (2004). "The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs". Nucleic Acids Res. 32 (8): 2411–20. doi:10.1093/nar/gkh552. PMC 419443. PMID 15121898.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000089157 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000067274 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9582194-5] Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.

[entrez-6] "Entrez Gene: RPLP0 ribosomal protein, large, P0".

RPLP0

References

Further reading