EIF4A3

Eukaryotic initiation factor 4A-III is a protein that in humans is encoded by the EIF4A3 gene.[5][6][7]

EIF4A3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEIF4A3, DDX48, MUK34, NMP265, NUK34, RCPS, eIF4AIII, eukaryotic translation initiation factor 4A3, Fal1, eIF4A-III, eIF-4A-III
External IDsOMIM: 608546 MGI: 1923731 HomoloGene: 5602 GeneCards: EIF4A3
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17q25.3Start80,134,369 bp[1]
End80,147,151 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9775

192170

Ensembl

ENSG00000141543

ENSMUSG00000025580

UniProt

P38919

Q91VC3

RefSeq (mRNA)

NM_014740

NM_138669

RefSeq (protein)

NP_055555

NP_619610

Location (UCSC)Chr 17: 80.13 – 80.15 MbChr 11: 119.29 – 119.3 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino acid sequences of the translation initiation factors eIF4A-I and eIF4A-II, two other members of the DEAD box protein family.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000141543 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000025580 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Holzmann K, Gerner C, Poltl A, Schafer R, Obrist P, Ensinger C, Grimm R, Sauermann G (Feb 2000). "A human common nuclear matrix protein homologous to eukaryotic translation initiation factor 4A". Biochem Biophys Res Commun. 267 (1): 339–44. doi:10.1006/bbrc.1999.1973. PMID 10623621.
  6. Chan CC, Dostie J, Diem MD, Feng W, Mann M, Rappsilber J, Dreyfuss G (Jan 2004). "eIF4A3 is a novel component of the exon junction complex". RNA. 10 (2): 200–9. doi:10.1261/rna.5230104. PMC 1370532. PMID 14730019.
  7. "Entrez Gene: EIF4A3 eukaryotic translation initiation factor 4A, isoform 3".

Further reading

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