MRPS2

Mitochondrial ribosomal protein S2 (MRPS2), otherwise known as uS2m, is a protein that in humans is encoded by the MRPS2 gene. [5]

MRPS2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRPS2, MRP-S2, S2mt, CGI-91, mitochondrial ribosomal protein S2, COXPD36
External IDsOMIM: 611971 MGI: 2153089 HomoloGene: 99837 GeneCards: MRPS2
Gene location (Human)
Chr.Chromosome 9 (human)[1]
Band9q34.3Start135,499,984 bp[1]
End135,504,673 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

51116

118451

Ensembl

ENSG00000122140

ENSMUSG00000035772

UniProt

Q9Y399

Q924T2

RefSeq (mRNA)

NM_016034
NM_001371401

NM_001166031
NM_080452

RefSeq (protein)

NP_057118
NP_001358330

NP_001159503
NP_536700

Location (UCSC)Chr 9: 135.5 – 135.5 MbChr 2: 28.47 – 28.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S2 family. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012].

See also

References
  1. GRCh38: Ensembl release 89: ENSG00000122140 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000035772 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Mitochondrial ribosomal protein S2". Retrieved 2018-02-11.

Further reading
  • Overview of all the structural information available in the PDB for UniProt: Q9Y399 (Human 28S ribosomal protein S2, mitochondrial (MRPS2)) at the PDBe-KB.

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