EEF2

Eukaryotic elongation factor 2 is a protein that in humans is encoded by the EEF2 gene. It is the archaeal and eukaryotic counterpart of bacterial EF-G.[5][6][7][8]

EEF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4V6X
Identifiers
Aliases	EEF2, EEF-2, EF-2, EF2, SCA26, eukaryotic translation elongation factor 2, Eukaryotic elongation factor 2
External IDs	OMIM: 130610 MGI: 95288 HomoloGene: 134867 GeneCards: EEF2
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 3,976,056 bp[1] End 3,985,463 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 81,176,631 bp[2] End 81,182,498 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • ribosome binding • GTP binding • p53 binding • translation elongation factor activity • actin filament binding • GO:0001948 protein binding • 5S rRNA binding • protein kinase binding • RNA binding • GTPase activity • cadherin binding Cellular component • cytoplasm • polysome • membrane • cell membrane • aggresome • membrane raft • extracellular exosome • cell nucleus • polysomal ribosome • extracellular matrix • extracellular region • cytosol • secretory granule lumen • ficolin-1-rich granule lumen • synapse • ribonucleoprotein Biological process • response to estradiol • positive regulation of cytoplasmic translation • skeletal muscle contraction • translational elongation • aging • positive regulation of translation • response to endoplasmic reticulum stress • cellular response to brain-derived neurotrophic factor stimulus • response to ischemia • hematopoietic progenitor cell differentiation • peptidyl-diphthamide biosynthetic process from peptidyl-histidine • glial cell proliferation • skeletal muscle cell differentiation • response to folic acid • response to ethanol • response to hydrogen peroxide • protein biosynthesis • protein methylation • response to drug • neutrophil degranulation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1938	13629
Ensembl	ENSG00000167658	ENSMUSG00000034994
UniProt	P13639	P58252
RefSeq (mRNA)	NM_001961	NM_007907
RefSeq (protein)	NP_001952	NP_031933
Location (UCSC)	Chr 19: 3.98 – 3.99 Mb	Chr 10: 81.18 – 81.18 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the ribosome. This protein is completely inactivated by EF-2 kinase phosphorylation.[7]

aEF2/eEF2 found in most archaea and eukaryotes, including humans, contains a post transcriptionally modified histidine diphthamide.[8] It is the target of diphtheria toxin (from Corynebacterium diphtheriae), and exotoxin A (from Pseudomonas aeruginosa).[9] The inactivation of EF-2 by toxins inhibits protein production in the host, causing symptoms due to loss of function in affected cells.