MRPL10

39S ribosomal protein L10, mitochondrial is a protein that in humans is encoded by the MRPL10 gene.[5][6]

MRPL10
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRPL10, L10MT, MRP-L10, MRP-L8, MRPL8, RPML8, mitochondrial ribosomal protein L10
External IDsOMIM: 611825 MGI: 1333801 HomoloGene: 41665 GeneCards: MRPL10
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17q21.32Start47,823,272 bp[1]
End47,831,541 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

124995

107732

Ensembl

ENSG00000159111

ENSMUSG00000001445

UniProt

Q7Z7H8

Q3TBW2

RefSeq (mRNA)

NM_145255
NM_148887

NM_026154
NM_001357807
NM_001357808

RefSeq (protein)

NP_660298
NP_683685

NP_080430
NP_001344736
NP_001344737

Location (UCSC)Chr 17: 47.82 – 47.83 MbChr 11: 97.04 – 97.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified two transcript variants that encode different isoforms. A pseudogene corresponding to this gene is found on chromosome 5q.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000159111 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000001445 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Koc EC, Burkhart W, Blackburn K, Moyer MB, Schlatzer DM, Moseley A, Spremulli LL (Nov 2001). "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present". J Biol Chem. 276 (47): 43958–69. doi:10.1074/jbc.M106510200. PMID 11551941.
  6. "Entrez Gene: MRPL10 mitochondrial ribosomal protein L10".

Further reading

  • Overview of all the structural information available in the PDB for UniProt: Q7Z7H8 (39S ribosomal protein L10, mitochondrial) at the PDBe-KB.


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