Sodium–hydrogen antiporter 1

SLC9A1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Y4E, 2BEC, 2E30, 2KBV, 2L0E, 2MDF, 2YGG
Identifiers
Aliases	SLC9A1, APNH, NHE-1, NHE1, PPP1R143, LIKNS, Sodium–hydrogen antiporter 1, solute carrier family 9 member A1
External IDs	MGI: 102462 HomoloGene: 20660 GeneCards: SLC9A1
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	27,166,981 bp[1]
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)[2]
End	133,423,702 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• protein binding, bridging; • calcium-dependent protein binding; • phosphatidylinositol-4,5-bisphosphate binding; • antiporter activity; • solute:proton antiporter activity; • sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential; • calmodulin binding; • protein binding; • protein complex scaffold activity; • protein phosphatase 2B binding; • sodium:proton antiporter activity; • potassium:proton antiporter activity;
Cellular component	• cytoplasm; • membrane; • focal adhesion; • T-tubule; • mitochondrion; • perinuclear region of cytoplasm; • cation-transporting ATPase complex; • cell surface; • apical plasma membrane; • endoplasmic reticulum; • membrane raft; • extracellular exosome; • lamellipodium; • integral component of membrane; • intercalated disc; • plasma membrane; • nucleoplasm; • endoplasmic reticulum membrane; • integral component of plasma membrane; • basolateral plasma membrane; • sarcolemma;
Biological process	• regulation of cardiac muscle contraction by calcium ion signaling; • regulation of sensory perception of pain; • positive regulation of the force of heart contraction; • positive regulation of cardiac muscle hypertrophy; • cellular response to epinephrine stimulus; • positive regulation of action potential; • cellular response to mechanical stimulus; • maintenance of cell polarity; • cellular response to hypoxia; • positive regulation of mitochondrial membrane permeability; • response to muscle stretch; • hydrogen ion transmembrane transport; • cellular sodium ion homeostasis; • cardiac muscle cell differentiation; • ion transport; • positive regulation of cell growth; • cellular response to insulin stimulus; • regulation of focal adhesion assembly; • sodium ion export; • regulation of cardiac muscle cell membrane potential; • response to acidic pH; • cell differentiation; • regulation of the force of heart contraction; • cellular response to organic cyclic compound; • cellular response to acidic pH; • cation transport; • negative regulation of apoptotic process; • regulation of the force of heart contraction by cardiac conduction; • regulation of pH; • cardiac muscle cell contraction; • neuron death; • hyaluronan catabolic process; • response to organic cyclic compound; • sodium ion transport; • regulation of intracellular pH; • positive regulation of intracellular signal transduction; • regulation of stress fiber assembly; • positive regulation of calcineurin-NFAT signaling cascade; • protein oligomerization; • sodium ion import across plasma membrane; • positive regulation of apoptotic process; • cellular response to antibiotic; • positive regulation of calcium:sodium antiporter activity; • cell migration; • positive regulation of transcription from RNA polymerase II promoter; • cellular response to electrical stimulus; • potassium ion transmembrane transport; • transmembrane transport; • transport; • cellular response to cold; • sodium ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	6548
	20544
	ENSG00000090020
	ENSMUSG00000028854
	P19634
	Q61165
	NM_003047
	NM_016981; NM_001358455
	NP_003038
	NP_058677; NP_001345384
	Wikidata
View/Edit Human	View/Edit Mouse

The sodium-hydrogen antiporter 1 (NHE-1) also known as sodium/hydrogen exchanger 1 or SLC9A1 (SoLute Carrier family 9A1) is an isoform of sodium–hydrogen antiporter that in humans is encoded by the SLC9A1 gene.^[5]

Function

The Na⁺/H⁺ antiporter (SLC9A1) is a ubiquitous membrane-bound enzyme involved in volume- and pH-regulation of vertebrate cells. It is inhibited by the non-specific diuretic drug amiloride and activated by a variety of signals including growth factors, mitogens, neurotransmitters, tumor promoters, and others.^[6]

Interactions

Sodium–hydrogen antiporter 1 has been shown to interact with carbonic anhydrase II^[7] and CHP.^[8]^[9]^[10] It is also the target of the experimental drug rimeporide, which is being developed for the treatment of Duchenne muscular dystrophy.^[11]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000090020 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028854 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Fliegel L, Dyck JR, Wang H, Fong C, Haworth RS (August 1993). "Cloning and analysis of the human myocardial Na+/H+ exchanger". Mol. Cell. Biochem. 125 (2): 137–43. doi:10.1007/BF00936442. PMID 8283968.
↑ Mattei MG, Sardet C, Franchi A, Pouysségur J (1988). "The human amiloride-sensitive Na+/H+ antiporter: localization to chromosome 1 by in situ hybridization". Cytogenet. Cell Genet. 48 (1): 6–8. doi:10.1159/000132575. PMID 2846238.
↑ Li X, Alvarez B, Casey JR, Reithmeier RA, Fliegel L (September 2002). "Carbonic anhydrase II binds to and enhances activity of the Na+/H+ exchanger". J. Biol. Chem. 277 (39): 36085–91. doi:10.1074/jbc.M111952200. PMID 12138085.
↑ Inoue H, Nakamura Y, Nagita M, Takai T, Masuda M, Nakamura N, Kanazawa H (February 2003). "Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium". Biol. Pharm. Bull. 26 (2): 148–55. doi:10.1248/bpb.26.148. PMID 12576672.
↑ Lin X, Barber DL (October 1996). "A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange". Proc. Natl. Acad. Sci. U.S.A. 93 (22): 12631–6. doi:10.1073/pnas.93.22.12631. PMC 38044. PMID 8901634.
↑ Pang T, Su X, Wakabayashi S, Shigekawa M (May 2001). "Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers". J. Biol. Chem. 276 (20): 17367–72. doi:10.1074/jbc.M100296200. PMID 11350981.
↑ Spreitzer, Helmut (26 May 2015). "Rimeporide". Österreichische Apothekerzeitung (in German). 69 (11): 12.

Yu L, Quinn DA, Garg HG, Hales CA (June 2008). "Deficiency of the NHE1 gene prevents hypoxia-induced pulmonary hypertension and vascular remodeling". Am. J. Respir. Crit. Care Med. 177 (11): 1276–84. doi:10.1164/rccm.200710-1522OC. PMC 2408441. PMID 18310478.
Rios EJ, Fallon M, Wang J, Shimoda LA (November 2005). "Chronic hypoxia elevates intracellular pH and activates Na+/H+ exchange in pulmonary arterial smooth muscle cells". Am. J. Physiol. Lung Cell Mol. Physiol. 289 (5): L867–74. doi:10.1152/ajplung.00455.2004. PMID 15964895.
Cingolani HE, Ennis IL (2007). "Sodium-hydrogen exchanger, cardiac overload, and myocardial hypertrophy". Circulation. 115 (9): 1090–100. doi:10.1161/CIRCULATIONAHA.106.626929. PMID 17339567.
Meima ME, Mackley JR, Barber DL (2007). "Beyond ion translocation: structural functions of the sodium-hydrogen exchanger isoform-1". Curr. Opin. Nephrol. Hypertens. 16 (4): 365–72. doi:10.1097/MNH.0b013e3281bd888d. PMID 17565280.
Tse CM, Ma AI, Yang VW, Watson AJ, Levine S, Montrose MH, Potter J, Sardet C, Pouyssegur J, Donowitz M (1991). "Molecular cloning and expression of a cDNA encoding the rabbit ileal villus cell basolateral membrane Na+/H+ exchanger". EMBO J. 10 (8): 1957–67. PMC 452875. PMID 1712287.
Dudley CR, Giuffra LA, Tippett P, Kidd KK, Reeders ST (1990). "The Na+/H+ antiporter: a "melt" polymorphism allows regional mapping to the short arm of chromosome 1". Hum. Genet. 86 (1): 79–83. doi:10.1007/bf00205179. PMID 1979310.
Sardet C, Counillon L, Franchi A, Pouysségur J (1990). "Growth factors induce phosphorylation of the Na+/H+ antiporter, glycoprotein of 110 kD". Science. 247 (4943): 723–6. doi:10.1126/science.2154036. PMID 2154036.
Sardet C, Franchi A, Pouysségur J (1989). "Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporter". Cell. 56 (2): 271–80. doi:10.1016/0092-8674(89)90901-X. PMID 2536298.
Mattei MG, Sardet C, Franchi A, Pouysségur J (1988). "The human amiloride-sensitive Na+/H+ antiporter: localization to chromosome 1 by in situ hybridization". Cytogenet. Cell Genet. 48 (1): 6–8. doi:10.1159/000132575. PMID 2846238.
Counillon L, Pouysségur J, Reithmeier RA (1994). "The Na+/H+ exchanger NHE-1 possesses N- and O-linked glycosylation restricted to the first N-terminal extracellular domain". Biochemistry. 33 (34): 10463–9. doi:10.1021/bi00200a030. PMID 8068684.
Fliegel L, Dyck JR, Wang H, Fong C, Haworth RS (1993). "Cloning and analysis of the human myocardial Na+/H+ exchanger". Mol. Cell. Biochem. 125 (2): 137–43. doi:10.1007/BF00936442. PMID 8283968.
Lin X, Barber DL (1996). "A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange". Proc. Natl. Acad. Sci. U.S.A. 93 (22): 12631–6. doi:10.1073/pnas.93.22.12631. PMC 38044. PMID 8901634.
Shrode LD, Gan BS, D'Souza SJ, Orlowski J, Grinstein S (1998). "Topological analysis of NHE1, the ubiquitous Na+/H+ exchanger using chymotryptic cleavage". Am. J. Physiol. 275 (2 Pt 1): C431–9. PMID 9688597.
Wakabayashi S, Pang T, Su X, Shigekawa M (2000). "A novel topology model of the human Na(+)/H(+) exchanger isoform 1". J. Biol. Chem. 275 (11): 7942–9. doi:10.1074/jbc.275.11.7942. PMID 10713111.
Garden OA, Musk P, Worthington-White DA, Dewey MJ, Rich IN (2000). "Silent polymorphisms within the coding region of human sodium/hydrogen exchanger isoform-1 cDNA in peripheral blood mononuclear cells of leukemia patients: A comparison with healthy controls". Cancer Genet. Cytogenet. 120 (1): 37–43. doi:10.1016/S0165-4608(99)00246-0. PMID 10913675.
Denker SP, Huang DC, Orlowski J, Furthmayr H, Barber DL (2000). "Direct binding of the Na--H exchanger NHE1 to ERM proteins regulates the cortical cytoskeleton and cell shape independently of H(+) translocation". Mol. Cell. 6 (6): 1425–36. doi:10.1016/S1097-2765(00)00139-8. PMID 11163215.
Lehoux S, Florian JA, Berk BC (2001). "14-3-3 Binding to Na+/H+ exchanger isoform-1 is associated with serum-dependent activation of Na+/H+ exchange". J. Biol. Chem. 276 (19): 15794–800. doi:10.1074/jbc.M100410200. PMID 11279064.
Pang T, Su X, Wakabayashi S, Shigekawa M (2001). "Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers". J. Biol. Chem. 276 (20): 17367–72. doi:10.1074/jbc.M100296200. PMID 11350981.
Yan W, Nehrke K, Choi J, Barber DL (2001). "The Nck-interacting kinase (NIK) phosphorylates the Na+-H+ exchanger NHE1 and regulates NHE1 activation by platelet-derived growth factor". J. Biol. Chem. 276 (33): 31349–56. doi:10.1074/jbc.M102679200. PMID 11369779.
Khaled AR, Moor AN, Li A, Kim K, Ferris DK, Muegge K, Fisher RJ, Fliegel L, Durum SK (2001). "Trophic factor withdrawal: p38 mitogen-activated protein kinase activates NHE1, which induces intracellular alkalinization". Mol. Cell. Biol. 21 (22): 7545–57. doi:10.1128/MCB.21.22.7545-7557.2001. PMC 99926. PMID 11604491.
Mailänder J, Müller-Esterl W, Dedio J (2001). "Human homolog of mouse tescalcin associates with Na(+)/H(+) exchanger type-1". FEBS Lett. 507 (3): 331–5. doi:10.1016/S0014-5793(01)02986-6. PMID 11696366.
Shen MR, Wilkins RJ, Chou CY, Ellory JC (2002). "Anion exchanger isoform 2 operates in parallel with Na(+)/H(+) exchanger isoform 1 during regulatory volume decrease of human cervical cancer cells". FEBS Lett. 512 (1–3): 52–8. doi:10.1016/S0014-5793(01)03317-8. PMID 11852051.
Behne MJ, Meyer JW, Hanson KM, Barry NP, Murata S, Crumrine D, Clegg RW, Gratton E, Holleran WM, Elias PM, Mauro TM (2002). "NHE1 regulates the stratum corneum permeability barrier homeostasis. Microenvironment acidification assessed with fluorescence lifetime imaging". J. Biol. Chem. 277 (49): 47399–406. doi:10.1074/jbc.M204759200. PMID 12221084.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000090020 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028854 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid8283968-5] Fliegel L, Dyck JR, Wang H, Fong C, Haworth RS (August 1993). "Cloning and analysis of the human myocardial Na+/H+ exchanger". Mol. Cell. Biochem. 125 (2): 137–43. doi:10.1007/BF00936442. PMID 8283968.

[pmid2846238-6] Mattei MG, Sardet C, Franchi A, Pouysségur J (1988). "The human amiloride-sensitive Na+/H+ antiporter: localization to chromosome 1 by in situ hybridization". Cytogenet. Cell Genet. 48 (1): 6–8. doi:10.1159/000132575. PMID 2846238.

[pmid12138085-7] Li X, Alvarez B, Casey JR, Reithmeier RA, Fliegel L (September 2002). "Carbonic anhydrase II binds to and enhances activity of the Na+/H+ exchanger". J. Biol. Chem. 277 (39): 36085–91. doi:10.1074/jbc.M111952200. PMID 12138085.

[pmid12576672-8] Inoue H, Nakamura Y, Nagita M, Takai T, Masuda M, Nakamura N, Kanazawa H (February 2003). "Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium". Biol. Pharm. Bull. 26 (2): 148–55. doi:10.1248/bpb.26.148. PMID 12576672.

[pmid8901634-9] Lin X, Barber DL (October 1996). "A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange". Proc. Natl. Acad. Sci. U.S.A. 93 (22): 12631–6. doi:10.1073/pnas.93.22.12631. PMC 38044. PMID 8901634.

[pmid11350981-10] Pang T, Su X, Wakabayashi S, Shigekawa M (May 2001). "Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers". J. Biol. Chem. 276 (20): 17367–72. doi:10.1074/jbc.M100296200. PMID 11350981.

[ÖAZ-11] Spreitzer, Helmut (26 May 2015). "Rimeporide". Österreichische Apothekerzeitung (in German). 69 (11): 12.

Sodium–hydrogen antiporter 1

Function

Interactions

References

Further reading