SLCO1A2

SLCO1A2
Identifiers
AliasesSLCO1A2, OATP, OATP-A, OATP1A2, SLC21A3, solute carrier organic anion transporter family member 1A2
External IDsMGI: 1351865 HomoloGene: 56603 GeneCards: SLCO1A2
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12p12.1Start21,264,600 bp[1]
End21,419,594 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

6579

108096

Ensembl

ENSG00000084453

ENSMUSG00000063975

UniProt

P46721

Q91YY5

RefSeq (mRNA)

NM_005075
NM_021094
NM_134431

NM_001267707
NM_130861

RefSeq (protein)

NP_066580
NP_602307

NP_001254636
NP_570931

Location (UCSC)Chr 12: 21.26 – 21.42 MbChr 6: 142.23 – 142.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Solute carrier organic anion transporter family member 1A2 is a protein that in humans is encoded by the SLCO1A2 gene.[5][6]

This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternate splicing of this gene results in three transcript variants encoding two different isoforms.[6]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000084453 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000063975 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Kullak-Ublick GA, Beuers U, Meier PJ, Domdey H, Paumgartner G (Apr 1997). "Assignment of the human organic anion transporting polypeptide (OATP) gene to chromosome 12p12 by fluorescence in situ hybridization". J Hepatol. 25 (6): 985–7. doi:10.1016/S0168-8278(96)80307-2. PMID 9007731.
  6. 1 2 "Entrez Gene: SLCO1A2 solute carrier organic anion transporter family, member 1A2".

Further reading

  • Meier PJ, Eckhardt U, Schroeder A, et al. (1998). "Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver". Hepatology. 26 (6): 1667–77. doi:10.1002/hep.510260641. PMID 9398014.
  • Kullak-Ublick GA, Hagenbuch B, Stieger B, et al. (1995). "Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver". Gastroenterology. 109 (4): 1274–82. doi:10.1016/0016-5085(95)90588-X. PMID 7557095.
  • Kullak-Ublick GA, Beuers U, Fahney C, et al. (1997). "Identification and functional characterization of the promoter region of the human organic anion transporting polypeptide gene". Hepatology. 26 (4): 991–7. doi:10.1002/hep.510260429. PMID 9328325.
  • Kullak-Ublick GA, Fisch T, Oswald M, et al. (1998). "Dehydroepiandrosterone sulfate (DHEAS): identification of a carrier protein in human liver and brain". FEBS Lett. 424 (3): 173–6. doi:10.1016/S0014-5793(98)00168-9. PMID 9539145.
  • König J, Cui Y, Nies AT, Keppler D (2000). "Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide". J. Biol. Chem. 275 (30): 23161–8. doi:10.1074/jbc.M001448200. PMID 10779507.
  • Tamai I, Nezu J, Uchino H, et al. (2000). "Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family". Biochem. Biophys. Res. Commun. 273 (1): 251–60. doi:10.1006/bbrc.2000.2922. PMID 10873595.
  • Speek M (2001). "Antisense Promoter of Human L1 Retrotransposon Drives Transcription of Adjacent Cellular Genes". Mol. Cell. Biol. 21 (6): 1973–85. doi:10.1128/MCB.21.6.1973-1985.2001. PMC 86790. PMID 11238933.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Lee W, Glaeser H, Smith LH, et al. (2005). "Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry". J. Biol. Chem. 280 (10): 9610–7. doi:10.1074/jbc.M411092200. PMID 15632119.
  • Su Y, Zhang X, Sinko PJ (2005). "Human organic anion-transporting polypeptide OATP-A (SLC21A3) acts in concert with P-glycoprotein and multidrug resistance protein 2 in the vectorial transport of Saquinavir in Hep G2 cells". Mol. Pharm. 1 (1): 49–56. doi:10.1021/mp0340136. PMID 15832500.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

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