SLC25A24

SLC34A1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4N5X, 4ZCU, 4ZCV
Identifiers
Aliases	SLC34A1, FRTS2, NAPI-3, NPHLOP1, NPT2, NPTIIa, SLC11, SLC17A2, solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24, APC1, SCAMC-1, SLC25A24, solute carrier family 25 member 24, solute carrier family 34 member 1, HCINF2
External IDs	MGI: 1345284 HomoloGene: 20663 GeneCards: SLC34A1
Gene location (Human)
Chr.	Chromosome 5 (human)[1]
End	177,398,848 bp[1]
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)[2]
End	55,415,592 bp[2]
Gene ontology
Molecular function	• protein homodimerization activity; • protein binding; • symporter activity; • sodium:phosphate symporter activity; • sodium-dependent phosphate transmembrane transporter activity; • PDZ domain binding; • macromolecular complex binding; • calcium ion binding; • ATP transmembrane transporter activity; • metal ion binding; • ADP transmembrane transporter activity; • transmembrane transporter activity;
Cellular component	• integral component of membrane; • endosome; • membrane; • intrinsic component of plasma membrane; • integral component of plasma membrane; • cell surface; • brush border membrane; • perinuclear region of cytoplasm; • membrane raft; • vesicle; • brush border; • cytoplasm; • plasma membrane; • apical plasma membrane; • nuclear speck; • mitotic spindle; • mitochondrion; • mitochondrial inner membrane;
Biological process	• cellular protein metabolic process; • phosphate ion transport; • response to potassium ion; • response to estradiol; • cellular response to staurosporine; • glycoprotein metabolic process; • response to cadmium ion; • ossification; • sodium-dependent phosphate transport; • positive regulation of phosphate transmembrane transport; • kidney development; • response to nutrient; • sodium ion transport; • response to thyroid hormone; • response to peptide hormone; • phosphate ion homeostasis; • response to magnesium ion; • dentinogenesis; • response to peptide; • response to vitamin A; • indole metabolic process; • cellular response to metal ion; • response to parathyroid hormone; • response to lead ion; • tricarboxylic acid metabolic process; • gentamycin metabolic process; • response to growth hormone; • arsenate ion transmembrane transport; • response to mercury ion; • cellular response to parathyroid hormone stimulus; • positive regulation of sodium-dependent phosphate transport; • positive regulation of membrane potential; • protein homooligomerization; • response to drug; • cellular phosphate ion homeostasis; • sodium ion transmembrane transport; • ion transport; • phosphate ion transmembrane transport; • sodium ion import across plasma membrane; • regulation of cell death; • cellular response to calcium ion; • cellular response to oxidative stress; • mitochondrial transport; • transmembrane transport; • ATP transport; • ADP transport;
	Sources:Amigo / QuickGO
Orthologs
	6569
	20505
	ENSG00000131183
	ENSMUSG00000021490
	Q06495; Q7Z725; Q6NUK1
	Q60825; Q9D2V6
	NM_001167579; NM_003052
	NM_011392
	NP_001161051; NP_003043; NP_003043.3; NP_037518; NP_998816
	NP_035522
	Wikidata
View/Edit Human	View/Edit Mouse

Solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 is a protein that in humans is encoded by the SLC25A24 gene.^[5]

Function

This gene encodes a carrier protein that transports ATP-Mg exchanging it for phosphate. Multiple transcript variants encoding different isoforms have been found for this gene.

References

Fiermonte G, De Leonardis F, Todisco S, Palmieri L, Lasorsa FM, Palmieri F (July 2004). "Identification of the mitochondrial ATP-Mg/Pi transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution". The Journal of Biological Chemistry. 279 (29): 30722–30. doi:10.1074/jbc.M400445200. PMID 15123600.
del Arco A, Satrústegui J (June 2004). "Identification of a novel human subfamily of mitochondrial carriers with calcium-binding domains". The Journal of Biological Chemistry. 279 (23): 24701–13. doi:10.1074/jbc.M401417200. PMID 15054102.
Traba J, Del Arco A, Duchen MR, Szabadkai G, Satrústegui J (April 2012). "SCaMC-1 promotes cancer cell survival by desensitizing mitochondrial permeability transition via ATP/ADP-mediated matrix Ca(2+) buffering". Cell Death and Differentiation. 19 (4): 650–60. doi:10.1038/cdd.2011.139. PMC 3307981. PMID 22015608.
Palmieri F (2013). "The mitochondrial transporter family SLC25: identification, properties and physiopathology". Molecular Aspects of Medicine. 34 (2–3): 465–84. doi:10.1016/j.mam.2012.05.005. PMID 23266187.
Jia L, Young MF, Powell J, Yang L, Ho NC, Hotchkiss R, Robey PG, Francomano CA (January 2002). "Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis". Genomics. 79 (1): 7–17. doi:10.1006/geno.2001.6683. PMID 11827452.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000131183 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021490 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[entrez-5] "Entrez Gene: Solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24".

SLC25A24

Function

References

Further reading