SLC7A1

SLC7A1
Identifiers
AliasesSLC7A1, ATRC1, CAT-1, ERR, HCAT1, REC1L, solute carrier family 7 member 1
External IDsMGI: 88117 HomoloGene: 20658 GeneCards: SLC7A1
Gene location (Human)
Chr.Chromosome 13 (human)[1]
Band13q12.3Start29,509,410 bp[1]
End29,595,688 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

6541

11987

Ensembl

ENSG00000139514

ENSMUSG00000041313

UniProt

P30825

Q09143

RefSeq (mRNA)

NM_003045

NM_001301424
NM_007513

RefSeq (protein)

NP_003036

NP_001288353
NP_031539

Location (UCSC)Chr 13: 29.51 – 29.6 MbChr 5: 148.33 – 148.4 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

High affinity cationic amino acid transporter 1 is a protein that in humans is encoded by the SLC7A1 gene.[5][6]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000139514 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041313 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Albritton LM, Bowcock AM, Eddy RL, Morton CC, Tseng L, Farrer LA, Cavalli-Sforza LL, Shows TB, Cunningham JM (March 1992). "The human cationic amino acid transporter (ATRC1): physical and genetic mapping to 13q12-q14". Genomics. 12 (3): 430–4. doi:10.1016/0888-7543(92)90431-Q. PMID 1348489.
  6. ↑ "Entrez Gene: SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1".

Further reading

  • Yoshimoto T, Yoshimoto E, Meruelo D (November 1991). "Molecular cloning and characterization of a novel human gene homologous to the murine ecotropic retroviral receptor". Virology. 185 (1): 10–7. doi:10.1016/0042-6822(91)90748-Z. PMID 1718082.
  • Kamath SG, Furesz TC, Way BA, Smith CH (September 1999). "Identification of three cationic amino acid transporters in placental trophoblast: cloning, expression, and characterization of hCAT-1". The Journal of Membrane Biology. 171 (1): 55–62. doi:10.1007/s002329900558. PMID 10485994.
  • Hammermann R, Brunn G, Racké K (2002). "Analysis of the genomic organization of the human cationic amino acid transporters CAT-1, CAT-2 and CAT-4". Amino Acids. 21 (2): 211–9. doi:10.1007/s007260170029. PMID 11665818.
  • Cariappa R, Heath-Monnig E, Furesz TC, Kamath SG, Smith CH (March 2002). "Stable polarized expression of hCAT-1 in an epithelial cell line". The Journal of Membrane Biology. 186 (1): 23–30. doi:10.1007/s00232-001-0133-y. PMID 11891586.
  • Furesz TC, Heath-Monnig E, Kamath SG, Smith CH (September 2002). "Lysine uptake by cloned hCAT-2B: comparison with hCAT-1 and with trophoblast surface membranes". The Journal of Membrane Biology. 189 (1): 27–33. doi:10.1007/s00232-002-1001-0. PMID 12202949.
  • Kizhatil K, Albritton LM (December 2002). "System y+ localizes to different membrane subdomains in the basolateral plasma membrane of epithelial cells". American Journal of Physiology. Cell Physiology. 283 (6): C1784–94. doi:10.1152/ajpcell.00061.2002. PMID 12388095.
  • Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Schnorr O, Suschek CV, Kolb-Bachofen V (June 2003). "The importance of cationic amino acid transporter expression in human skin". The Journal of Investigative Dermatology. 120 (6): 1016–22. doi:10.1046/j.1523-1747.2003.12139.x. PMID 12787129.
  • González M, Flores C, Pearson JD, Casanello P, Sobrevia L (July 2004). "Cell signalling-mediating insulin increase of mRNA expression for cationic amino acid transporters-1 and -2 and membrane hyperpolarization in human umbilical vein endothelial cells". Pflügers Archiv. 448 (4): 383–94. doi:10.1007/s00424-004-1261-x. PMID 15064952.
  • Schwartz IF, Iaina A, Benedict Y, Wollman Y, Chernichovski T, Brasowski E, Misonzhnik F, Ben-Dor A, Blum M, Levo Y, Schwartz D (April 2004). "Augmented arginine uptake, through modulation of cationic amino acid transporter-1, increases GFR in diabetic rats". Kidney International. 65 (4): 1311–9. doi:10.1111/j.1523-1755.2004.00508.x. PMID 15086470.
  • Rotmann A, Strand D, Martiné U, Closs EI (December 2004). "Protein kinase C activation promotes the internalization of the human cationic amino acid transporter hCAT-1. A new regulatory mechanism for hCAT-1 activity". The Journal of Biological Chemistry. 279 (52): 54185–92. doi:10.1074/jbc.M409556200. PMID 15491978.
  • Cui Z, Tuladhar R, Hart SL, Marber MS, Pearson JD, Baydoun AR (February 2005). "Rate of transport of l-arginine is independent of the expression of inducible nitric oxide synthase in HEK 293 cells". Nitric Oxide. 12 (1): 21–30. doi:10.1016/j.niox.2004.11.001. PMID 15631944.
  • Yang Z, Venardos K, Jones E, Morris BJ, Chin-Dusting J, Kaye DM (March 2007). "Identification of a novel polymorphism in the 3'UTR of the L-arginine transporter gene SLC7A1: contribution to hypertension and endothelial dysfunction". Circulation. 115 (10): 1269–74. doi:10.1161/CIRCULATIONAHA.106.665836. PMID 17325243.
  • Kaneko S, Okuda-Ashitaka E, Ando A, Nishimura K, Igarashi K, Maeda M, Furuta K, Suzuki M, Matsumura M, Ito S (August 2007). "Polyamines upregulate the mRNA expression of cationic amino acid transporter-1 in human retinal pigment epithelial cells". American Journal of Physiology. Cell Physiology. 293 (2): C729–37. doi:10.1152/ajpcell.00018.2007. PMID 17494634.


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