SLC30A1

SLC30A1
Identifiers
AliasesSLC30A1, ZNT1, ZRC1, solute carrier family 30 member 1
External IDsMGI: 1345281 HomoloGene: 6681 GeneCards: SLC30A1
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q32.3Start211,571,568 bp[1]
End211,578,742 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

7779

22782

Ensembl

ENSG00000170385

ENSMUSG00000037434

UniProt

Q9Y6M5

Q60738

RefSeq (mRNA)

NM_021194

NM_009579

RefSeq (protein)

NP_067017

NP_033605

Location (UCSC)Chr 1: 211.57 – 211.58 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Solute carrier family 30 (zinc transporter), member 1 is a protein which in humans is encoded by the SLC30A1 gene.[4][5]

Function

SLC30A1 modulates zinc permeation through the L-type calcium channel. SLC30A1 downregulates not only Zn++ influx, but also Ca++ influx, thereby protecting cells from the effects of excessive cation permeation.[6]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000170385 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:".
  3. ↑ "Mouse PubMed Reference:".
  4. ↑ Palmiter RD, Findley SD (February 1995). "Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc". The EMBO Journal. 14 (4): 639–49. PMC 398127. PMID 7882967.
  5. ↑ Seve M, Chimienti F, Devergnas S, Favier A (May 2004). "In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression". BMC Genomics. 5 (1): 32. doi:10.1186/1471-2164-5-32. PMC 428573. PMID 15154973.
  6. ↑ Segal D, Ohana E, Besser L, Hershfinkel M, Moran A, Sekler I (October 2004). "A role for ZnT-1 in regulating cellular cation influx". Biochemical and Biophysical Research Communications. 323 (4): 1145–50. doi:10.1016/j.bbrc.2004.08.211. PMID 15451416.

Further reading

  • Guey LT, GarcÃa-Closas M, Murta-Nascimento C, et al. (2009). "Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes". Eur. Urol. 57 (2): HASH(0x24ec9d0). doi:10.1016/j.eururo.2009.08.001. PMC 3220186. PMID 19692168.
  • Zhang LH, Wang X, Stoltenberg M, et al. (2008). "Abundant expression of zinc transporters in the amyloid plaques of Alzheimer's disease brain". Brain Res. Bull. 77 (1): 55–60. doi:10.1016/j.brainresbull.2008.03.014. PMID 18639746.
  • Lovell MA, Smith JL, Xiong S, Markesbery WR (2005). "Alterations in zinc transporter protein-1 (ZnT-1) in the brain of subjects with mild cognitive impairment, early, and late-stage Alzheimer's disease". Neurotoxicity research. 7 (4): 265–71. doi:10.1007/BF03033884. PMID 16179263.
  • Zhang LY, Wang XL, Sun DX, et al. (2008). "Regulation of zinc transporters by dietary flaxseed lignan in human breast cancer xenografts". Mol. Biol. Rep. 35 (4): 595–600. doi:10.1007/s11033-007-9129-8. PMID 17786585.
  • Iguchi K, Otsuka T, Usui S, et al. (2004). "Zinc and metallothionein levels and expression of zinc transporters in androgen-independent subline of LNCaP cells". J. Androl. 25 (1): 154–61. PMID 14662799.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Lazarczyk M, Pons C, Mendoza JA, et al. (2008). "Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses". J. Exp. Med. 205 (1): 35–42. doi:10.1084/jem.20071311. PMC 2234378. PMID 18158319.
  • Overbeck S, Uciechowski P, Ackland ML, et al. (2008). "Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9". J. Leukoc. Biol. 83 (2): 368–80. doi:10.1189/jlb.0307148. PMID 17971500.
  • Hosgood HD, Menashe I, He X, et al. (2009). "PTEN identified as important risk factor of chronic obstructive pulmonary disease". Respiratory medicine. 103 (12): HASH(0x15616e0). doi:10.1016/j.rmed.2009.06.016. PMC 2783799. PMID 19625176.
  • Hosgood HD, Menashe I, Shen M, et al. (2008). "Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway". Carcinogenesis. 29 (10): 1938–43. doi:10.1093/carcin/bgn178. PMC 2722857. PMID 18676680.
  • Etzion Y, Ganiel A, Beharier O, et al. (2008). "Correlation between atrial ZnT-1 expression and atrial fibrillation in humans: a pilot study". J. Cardiovasc. Electrophysiol. 19 (2): 157–64. doi:10.1111/j.1540-8167.2007.01008.x. PMID 17971132.
  • Barbe L, Lundberg E, Oksvold P, et al. (2008). "Toward a confocal subcellular atlas of the human proteome". Mol. Cell. Proteomics. 7 (3): 499–508. doi:10.1074/mcp.M700325-MCP200. PMID 18029348.


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