Sodium–hydrogen antiporter 2

SLC9A2
Identifiers
AliasesSLC9A2, NHE2, solute carrier family 9 member A2
External IDsMGI: 105075 HomoloGene: 20661 GeneCards: SLC9A2
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q12.1Start102,619,707 bp[1]
End102,711,318 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

6549

226999

Ensembl

ENSG00000115616

ENSMUSG00000026062

UniProt

Q9UBY0

n/a

RefSeq (mRNA)

NM_003048

NM_001033289

RefSeq (protein)

NP_003039

n/a

Location (UCSC)Chr 2: 102.62 – 102.71 MbChr 1: 40.68 – 40.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sodium–hydrogen exchanger 2 is a protein that in humans is encoded by the SLC9A2 gene.[5]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000115616 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026062 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: SLC9A2 solute carrier family 9 (sodium/hydrogen exchanger), member 2".

Further reading

  • Chow CW (1999). "Regulation and intracellular localization of the epithelial isoforms of the Na+/H+ exchangers NHE2 and NHE3". Clinical and investigative medicine. Médecine clinique et experimentale. 22 (5): 195–206. PMID 10579058.
  • Kulanthaivel P, Furesz TC, Moe AJ, et al. (1992). "Human placental syncytiotrophoblast expresses two pharmacologically distinguishable types of Na(+)-H+ exchangers, NHE-1 in the maternal-facing (brush border) membrane and NHE-2 in the fetal-facing (basal) membrane". Biochem. J. 284 (1): 33–8. PMC 1132693. PMID 1318024.
  • Collins JF, Honda T, Knobel S, et al. (1993). "Molecular cloning, sequencing, tissue distribution, and functional expression of a Na+/H+ exchanger (NHE-2)". Proc. Natl. Acad. Sci. U.S.A. 90 (9): 3938–42. doi:10.1073/pnas.90.9.3938. PMC 46421. PMID 7683411.
  • Ghishan FK, Knobel SM, Summar M (1996). "Molecular cloning, sequencing, chromosomal localization, and tissue distribution of the human Na+/H+ exchanger (SLC9A2)". Genomics. 30 (1): 25–30. doi:10.1006/geno.1995.0004. PMID 8595899.
  • Dudeja PK, Rao DD, Syed I, et al. (1996). "Intestinal distribution of human Na+/H+ exchanger isoforms NHE-1, NHE-2, and NHE-3 mRNA". Am. J. Physiol. 271 (3 Pt 1): G483–93. PMID 8843774.
  • Lin X, Barber DL (1996). "A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange". Proc. Natl. Acad. Sci. U.S.A. 93 (22): 12631–6. doi:10.1073/pnas.93.22.12631. PMC 38044. PMID 8901634.
  • "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
  • Chow CW, Woodside M, Demaurex N, et al. (1999). "Proline-rich motifs of the Na+/H+ exchanger 2 isoform. Binding of Src homology domain 3 and role in apical targeting in epithelia". J. Biol. Chem. 274 (15): 10481–8. doi:10.1074/jbc.274.15.10481. PMID 10187839.
  • Malakooti J, Dahdal RY, Schmidt L, et al. (1999). "Molecular cloning, tissue distribution, and functional expression of the human Na(+)/H(+) exchanger NHE2". Am. J. Physiol. 277 (2 Pt 1): G383–90. PMID 10444453.
  • Malakooti J, Dahdal RY, Dudeja PK, et al. (2001). "The human Na(+)/H(+) exchanger NHE2 gene: genomic organization and promoter characterization". Am. J. Physiol. Gastrointest. Liver Physiol. 280 (4): G763–73. PMID 11254504.
  • Pang T, Su X, Wakabayashi S, Shigekawa M (2001). "Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers". J. Biol. Chem. 276 (20): 17367–72. doi:10.1074/jbc.M100296200. PMID 11350981.
  • Repishti M, Hogan DL, Pratha V, et al. (2001). "Human duodenal mucosal brush border Na(+)/H(+) exchangers NHE2 and NHE3 alter net bicarbonate movement". Am. J. Physiol. Gastrointest. Liver Physiol. 281 (1): G159–63. PMID 11408268.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Lacey HA, Nolan T, Greenwood SL, et al. (2005). "Gestational profile of Na+/H+ exchanger and Cl-/HCO3- anion exchanger mRNA expression in placenta using real-time QPCR". Placenta. 26 (1): 93–8. doi:10.1016/j.placenta.2004.05.005. PMID 15664417.
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
  • Pearse I, Zhu YX, Murray EJ, et al. (2007). "Sp1 and Sp3 control constitutive expression of the human NHE2 promoter by interactions with the proximal promoter and the transcription initiation site". Biochem. J. 407 (1): 101–11. doi:10.1042/BJ20070364. PMC 2267401. PMID 17561809.


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