SLC25A11

SLC25A11
Identifiers
AliasesSLC25A11, OGC, SLC20A4, solute carrier family 25 member 11
External IDsMGI: 1915113 HomoloGene: 2637 GeneCards: SLC25A11
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17p13.2Start4,937,130 bp[1]
End4,940,251 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8402

67863

Ensembl

ENSG00000108528

ENSMUSG00000014606

UniProt

Q02978

Q9CR62

RefSeq (mRNA)

NM_003562
NM_001165417
NM_001165418

NM_024211

RefSeq (protein)

NP_001158889
NP_001158890
NP_003553

NP_077173

Location (UCSC)Chr 17: 4.94 – 4.94 MbChr 11: 70.64 – 70.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mitochondrial 2-oxoglutarate/malate carrier protein is a protein that in humans is encoded by the SLC25A11 gene.[5][6][7] Inactivating mutations in this gene predispose to metastasic paraganglioma.[8]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000108528 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000014606 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Piccininni S, Iacobazzi V, Lauria G, Rocchi M, Palmieri F (Mar 1999). "Assignment of the oxoglutarate carrier gene (SLC20A4) to human chromosome 17p13.3". Cytogenet Cell Genet. 83 (3–4): 256–7. doi:10.1159/000015198. PMID 10072597.
  6. ↑ Iacobazzi V, Palmieri F, Runswick MJ, Walker JE (Jan 1993). "Sequences of the human and bovine genes for the mitochondrial 2-oxoglutarate carrier". DNA Seq. 3 (2): 79–88. doi:10.3109/10425179209034000. PMID 1457818.
  7. ↑ "Entrez Gene: SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11".
  8. ↑ Buffet, Alexandre; Morin, Aurelie; Castro-Vega, Luis-Jaime; Habarou, Florence; Lussey-Lepoutre, Charlotte; Letouzé, Eric; Lefebvre, Hervé; Guilhem, Isabelle; Magalie, Haissaguerre (2018-02-05). "Germline mutations in the mitochondrial 2-oxoglutarate/malate carrier SLC25A11 gene confer a predisposition to metastatic paragangliomas". Cancer Research. doi:10.1158/0008-5472.CAN-17-2463. ISSN 1538-7445. PMID 29431636.

Further reading

  • Bisaccia F, Zara V, Capobianco L, et al. (1996). "The formation of a disulfide cross-link between the two subunits demonstrates the dimeric structure of the mitochondrial oxoglutarate carrier". Biochim. Biophys. Acta. 1292 (2): 281–88. doi:10.1016/0167-4838(95)00215-4. PMID 8597574.
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Bisaccia F, Capobianco L, Mazzeo M, Palmieri F (1996). "The mitochondrial oxoglutarate carrier protein contains a disulfide bridge between intramembranous cysteines 221 and 224". FEBS Lett. 392 (1): 54–8. doi:10.1016/0014-5793(96)00784-3. PMID 8769314.
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Palmisano A, Zara V, Hönlinger A, et al. (1998). "Targeting and assembly of the oxoglutarate carrier: general principles for biogenesis of carrier proteins of the mitochondrial inner membrane". Biochem. J. 333 ( Pt 1) (Pt 1): 151–8. PMC 1219567. PMID 9639574.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Coll O, Colell A, García-Ruiz C, et al. (2003). "Sensitivity of the 2-oxoglutarate carrier to alcohol intake contributes to mitochondrial glutathione depletion". Hepatology. 38 (3): 692–702. doi:10.1053/jhep.2003.50351. PMID 12939596.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Kabe Y, Ohmori M, Shinouchi K, et al. (2006). "Porphyrin accumulation in mitochondria is mediated by 2-oxoglutarate carrier". J. Biol. Chem. 281 (42): 31729–35. doi:10.1074/jbc.M604729200. PMID 16920706.


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