Ethoheptazine

Ethoheptazine
Clinical data
Trade names Equagesic
Synonyms Zactane
Routes of
administration		 Oral
ATC code
  • none
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
ChEMBL
ECHA InfoCard 100.000.917 Edit this at Wikidata
Chemical and physical data
Formula C16H23NO2
Molar mass 261.36 g/mol
3D model (JSmol)
 ☒N☑Y (what is this?)  (verify)

Ethoheptazine[1] (trade name Zactane) is an opioid analgesic from the phenazepane family. It was invented in the 1950s[2] and is related to other drugs such as proheptazine and pethidine.[3]

Ethoheptazine produces similar effects to other opioids, including analgesia, sedation, dizziness and nausea.[4] It was sold by itself as Zactane, and is still available as a combination product with acetylsalicylic acid and meprobamate as Equagesic, which is used for the treatment of conditions where both pain and anxiety are present.[5] It was also investigated for use as an antitussive.[6]

It's no longer Prescribed, as it's no longer FDA Approved, and not available for United State's Pharmacy Processing. Revocation of FDA Approved Medications Status stems from a combination of efficacy vs. toxicity, and the more-varied and historically safer Benzodiazepines Class. Only reversal of the FDA's decision, allows removing the drug from the CSD. Ethoheptazine is not listed as a controlled substance under the Controlled Substances Act, 1970 in the United States.[7] The controlled status (Schedule IV) of Equagesic was due to the meprobamate content.[8][9] Regulation elsewhere varies. The Canadian Controlled Drugs & Substances act specifically excludes the phenazepine opioids, including proheptazine, from control.[10]

References

  1. ↑ ES Patent 310184
  2. ↑ Batterman RC, Golbey M, Grossman AJ, Leifer P. Analgesic effectiveness of orally administered ethoheptazine in man. American Journal of the Medical Sciences. 1957 Oct;234(4):413-9.
  3. ↑ Diamond J, Bruce WF, Tyson FT. Synthesis and Properties of the Analgesic DL-α-1,3-dimethyl-4-phenyl-4-propionoxyazacycloheptane (Proheptazine). Journal of Medicinal Chemistry. 1964 Jan;7:57-60.
  4. ↑ Cinelli P, Zucchini M. Current pharmaco-therapeutic possibilities in the treatment of pain. Experiments with ethoeptazine. (Italian). Minerva Medica. 1962 Mar 3;53:637-42.
  5. ↑ Scheiner JJ, Richards DJ. Treatment of musculoskeletal pain and associated anxiety with an ethoheptazine-aspirin-meprobamate combination (equagesic): a controlled study. Current Therapeutic Research, Clinical and Experimental. 1974 Sep;16(9):928-36.
  6. ↑ J Pharmacol Exp Ther November 1979 211:401-408
  7. ↑ http://www.deadiversion.usdoj.gov/quotas/conv_factor/index.html
  8. ↑ PDR 1978, pp 1618
  9. ↑ http://www.deadiversion.usdoj.gov/quotas/conv_factor/index.html
  10. ↑ http://laws-lois.justice.gc.ca/eng/acts/C-38.8/


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.