RS-127445

RS-127445 is a drug which acts as a potent and selective antagonist at the serotonin 5-HT2B receptor, with around 1000x selectivity over the closely related 5-HT2A and 5-HT2C receptors.[1] The role of the 5-HT2B receptor in the body is still poorly understood, and RS-127445 has been a useful tool in unravelling the function of the various systems in which this receptor is expressed.[2][3][4]

RS-127445
Clinical data
Other namesRS-127,445
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC17H16FN3
Molar mass281.334 g·mol−1
3D model (JSmol)
  (verify)

References

  1. Bonhaus DW, Flippin LA, Greenhouse RJ, Jaime S, Rocha C, Dawson M, et al. (July 1999). "RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist". British Journal of Pharmacology. 127 (5): 1075–82. doi:10.1038/sj.bjp.0702632. PMC 1566110. PMID 10455251.
  2. Launay JM, Hervé P, Peoc'h K, Tournois C, Callebert J, Nebigil CG, et al. (October 2002). "Function of the serotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertension". Nature Medicine. 8 (10): 1129–35. doi:10.1038/nm764. PMID 12244304.
  3. Kelly CR, Sharif NA (June 2006). "Pharmacological evidence for a functional serotonin-2B receptor in a human uterine smooth muscle cell line". The Journal of Pharmacology and Experimental Therapeutics. 317 (3): 1254–61. doi:10.1124/jpet.105.100172. PMID 16517693.
  4. Mbaki Y, Ramage AG (October 2008). "Investigation of the role of 5-HT2 receptor subtypes in the control of the bladder and the urethra in the anaesthetized female rat". British Journal of Pharmacology. 155 (3): 343–56. doi:10.1038/bjp.2008.273. PMC 2567885. PMID 18604238.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.