EPHB3

Ephrin type-B receptor 3 is a protein that in humans is encoded by the EPHB3 gene.[5][6]

EPHB3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEPHB3, ETK2, HEK2, TYRO6, EPH receptor B3, EK2
External IDsOMIM: 601839 MGI: 104770 HomoloGene: 20938 GeneCards: EPHB3
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3q27.1Start184,561,785 bp[1]
End184,582,408 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

2049

13845

Ensembl

ENSG00000182580

ENSMUSG00000005958

UniProt

P54753

P54754

RefSeq (mRNA)

NM_004443

NM_010143

RefSeq (protein)

NP_004434

NP_034273

Location (UCSC)Chr 3: 184.56 – 184.58 MbChr 16: 21.2 – 21.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.[6]

Interactions

EPHB3 has been shown to interact with MLLT4[7] and RAS p21 protein activator 1.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000182580 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000005958 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Böhme B, Holtrich U, Wolf G, Luzius H, Grzeschik KH, Strebhardt K, Rübsamen-Waigmann H (Oct 1993). "PCR mediated detection of a new human receptor-tyrosine-kinase, HEK 2". Oncogene. 8 (10): 2857–62. PMID 8397371.
  6. "Entrez Gene: EPHB3 EPH receptor B3".
  7. Hock B, Böhme B, Karn T, Yamamoto T, Kaibuchi K, Holtrich U, Holland S, Pawson T, Rübsamen-Waigmann H, Strebhardt K (Aug 1998). "PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 9779–84. Bibcode:1998PNAS...95.9779H. doi:10.1073/pnas.95.17.9779. PMC 21413. PMID 9707552.
  8. Hock B, Böhme B, Karn T, Feller S, Rübsamen-Waigmann H, Strebhardt K (Jul 1998). "Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions". Oncogene. 17 (2): 255–60. doi:10.1038/sj.onc.1201907. PMID 9674711.

Further reading

  • Overview of all the structural information available in the PDB for UniProt: P54753 (Ephrin type-B receptor 3) at the PDBe-KB.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.