YES1

YES1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2HDA
Identifiers
Aliases	YES1, HsT441, P61-YES, Yes, c-yes, YES proto-oncogene 1, Src family tyrosine kinase
External IDs	OMIM: 164880 MGI: 99147 HomoloGene: 55900 GeneCards: YES1
Gene location (Human)
Chr.	Chromosome 18 (human)[1]
End	812,546 bp[1]
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)[2]
End	32,687,057 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• transferase activity; • nucleotide binding; • protein kinase activity; • ion channel binding; • epidermal growth factor receptor binding; • non-membrane spanning protein tyrosine kinase activity; • kinase activity; • GO:0001948 protein binding; • enzyme binding; • protein tyrosine kinase activity; • receptor binding; • ATP binding; • phosphotyrosine residue binding;
Cellular component	• Golgi apparatus; • membrane; • focal adhesion; • extrinsic component of cytoplasmic side of plasma membrane; • cell membrane; • microtubule organizing center; • actin filament; • extracellular exosome; • cytoskeleton; • cytoplasm; • cytosol; • glutamatergic synapse; • postsynaptic specialization, intracellular component;
Biological process	• cellular response to transforming growth factor beta stimulus; • cellular response to retinoic acid; • cell differentiation; • Fc-gamma receptor signaling pathway involved in phagocytosis; • phosphorylation; • transmembrane receptor protein tyrosine kinase signaling pathway; • ephrin receptor signaling pathway; • T cell costimulation; • cellular response to platelet-derived growth factor stimulus; • protein phosphorylation; • regulation of vascular permeability; • cellular protein modification process; • regulation of cell proliferation; • positive regulation of peptidyl-tyrosine phosphorylation; • peptidyl-tyrosine autophosphorylation; • autophosphorylation; • leukocyte migration; • glucose transport; • positive regulation of transcription from RNA polymerase II promoter; • innate immune system; • cell migration; • regulation of glucose transport;
	Sources:Amigo / QuickGO
Orthologs
	7525
	22612
	ENSG00000176105
	ENSMUSG00000014932
	P07947
	Q04736
	NM_005433
	NM_001205132; NM_001205133; NM_009535
	NP_005424
	NP_001192061; NP_001192062; NP_033561
	Wikidata
View/Edit Human	View/Edit Mouse

Proto-oncogene tyrosine-protein kinase Yes is an enzyme that in humans is encoded by the YES1 gene.[5][6]

This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22.[6]

Interactions

YES1 has been shown to interact with Janus kinase 2,[7] CTNND1,[8] RPL10[9] and Occludin.[10]

References

GRCh38: Ensembl release 89: ENSG00000176105 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000014932 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Semba K, Yamanashi Y, Nishizawa M, Sukegawa J, Yoshida M, Sasaki M, Yamamoto T, Toyoshima K (Mar 1985). "Location of the c-yes gene on the human chromosome and its expression in various tissues". Science. 227 (4690): 1038–40. Bibcode:1985Sci...227.1038S. doi:10.1126/science.2983418. PMID 2983418.
"Entrez Gene: YES1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1".
Fuhrer, D K; Yang Y C (Jul 1996). "Complex formation of JAK2 with PP2A, P13K, and Yes in response to the hematopoietic cytokine interleukin-11". Biochem. Biophys. Res. Commun. 224 (2): 289–96. doi:10.1006/bbrc.1996.1023. ISSN 0006-291X. PMID 8702385.
Piedra, Jose; Miravet Susana; Castaño Julio; Pálmer Héctor G; Heisterkamp Nora; García de Herreros Antonio; Duñach Mireia (Apr 2003). "p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction" (PDF). Mol. Cell. Biol. 23 (7): 2287–97. doi:10.1128/MCB.23.7.2287-2297.2003. ISSN 0270-7306. PMC 150740. PMID 12640114.
Oh, Hyung Suk; Kwon Haeyoung; Sun Suk Kyun; Yang Chul-Hak (Sep 2002). "QM, a putative tumor suppressor, regulates proto-oncogene c-yes". J. Biol. Chem. 277 (39): 36489–98. doi:10.1074/jbc.M201859200. ISSN 0021-9258. PMID 12138090.
Chen, Yan-Hua; Lu Qun; Goodenough Daniel A; Jeansonne Beverly (Apr 2002). "Nonreceptor tyrosine kinase c-Yes interacts with occludin during tight junction formation in canine kidney epithelial cells". Mol. Biol. Cell. 13 (4): 1227–37. doi:10.1091/mbc.01-08-0423. ISSN 1059-1524. PMC 102264. PMID 11950934.

External links

Overview of all the structural information available in the PDB for UniProt: P07947 (Tyrosine-protein kinase Yes) at the PDBe-KB.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000176105 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000014932 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2983418-5] Semba K, Yamanashi Y, Nishizawa M, Sukegawa J, Yoshida M, Sasaki M, Yamamoto T, Toyoshima K (Mar 1985). "Location of the c-yes gene on the human chromosome and its expression in various tissues". Science. 227 (4690): 1038–40. Bibcode:1985Sci...227.1038S. doi:10.1126/science.2983418. PMID 2983418.

[entrez-6] "Entrez Gene: YES1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1".

[pmid8702385-7] Fuhrer, D K; Yang Y C (Jul 1996). "Complex formation of JAK2 with PP2A, P13K, and Yes in response to the hematopoietic cytokine interleukin-11". Biochem. Biophys. Res. Commun. 224 (2): 289–96. doi:10.1006/bbrc.1996.1023. ISSN 0006-291X. PMID 8702385.

[pmid12640114-8] Piedra, Jose; Miravet Susana; Castaño Julio; Pálmer Héctor G; Heisterkamp Nora; García de Herreros Antonio; Duñach Mireia (Apr 2003). "p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction" (PDF). Mol. Cell. Biol. 23 (7): 2287–97. doi:10.1128/MCB.23.7.2287-2297.2003. ISSN 0270-7306. PMC 150740. PMID 12640114.

[pmid12138090-9] Oh, Hyung Suk; Kwon Haeyoung; Sun Suk Kyun; Yang Chul-Hak (Sep 2002). "QM, a putative tumor suppressor, regulates proto-oncogene c-yes". J. Biol. Chem. 277 (39): 36489–98. doi:10.1074/jbc.M201859200. ISSN 0021-9258. PMID 12138090.

[pmid11950934-10] Chen, Yan-Hua; Lu Qun; Goodenough Daniel A; Jeansonne Beverly (Apr 2002). "Nonreceptor tyrosine kinase c-Yes interacts with occludin during tight junction formation in canine kidney epithelial cells". Mol. Biol. Cell. 13 (4): 1227–37. doi:10.1091/mbc.01-08-0423. ISSN 1059-1524. PMC 102264. PMID 11950934.

YES1

Interactions

References

Further reading

External links