Fyn-related kinase

FRK
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2D8J, 2DLY
Identifiers
Aliases	FRK, GTK, PTK5, RAK, Fyn-related kinase, fyn related Src family tyrosine kinase
External IDs	OMIM: 606573 MGI: 103265 HomoloGene: 48065 GeneCards: FRK
Gene location (Human)
Chr.	Chromosome 6 (human)[1]
End	116,060,891 bp[1]
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)[2]
End	34,611,278 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• transferase activity; • nucleotide binding; • protein kinase activity; • kinase activity; • GO:0001948 protein binding; • receptor binding; • ATP binding; • non-membrane spanning protein tyrosine kinase activity; • protein tyrosine kinase activity;
Cellular component	• extrinsic component of cytoplasmic side of plasma membrane; • cell membrane; • intracellular; • extracellular exosome; • extracellular region; • cell nucleus; • nucleoplasm; • cytoplasm; • azurophil granule lumen; • specific granule lumen; • cytosol;
Biological process	• cell differentiation; • phosphorylation; • transmembrane receptor protein tyrosine kinase signaling pathway; • negative regulation of transcription from RNA polymerase II promoter; • protein phosphorylation; • peptidyl-tyrosine autophosphorylation; • innate immune system; • negative regulation of cell proliferation; • neutrophil degranulation; • cell migration;
	Sources:Amigo / QuickGO
Orthologs
	2444
	14302
	ENSG00000111816
	ENSMUSG00000019779
	P42685
	Q922K9
	NM_002031
	NM_001159544; NM_010237; NM_001358769
	NP_002022
	NP_001153016; NP_034367; NP_001345698
	Wikidata
View/Edit Human	View/Edit Mouse

Fyn-related kinase (FRK, formerly tyrosine protein kinase 5) is an enzyme that in humans is encoded by the FRK gene.[5][6]

The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth.[6]

Interactions

FRK has been shown to interact with retinoblastoma protein.[7]

References

GRCh38: Ensembl release 89: ENSG00000111816 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000019779 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Lee J, Wang Z, Luoh SM, Wood WI, Scadden DT (April 1994). "Cloning of FRK, a novel human intracellular SRC-like tyrosine kinase-encoding gene". Gene. 138 (1–2): 247–51. doi:10.1016/0378-1119(94)90817-6. PMID 7510261.
"Entrez Gene: FRK fyn-related kinase".
Craven, R J; Cance W G; Liu E T (September 1995). "The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb". Cancer Res. UNITED STATES. 55 (18): 3969–72. ISSN 0008-5472. PMID 7664264.

Serfas MS, Tyner AL (2003). "Brk, Srm, Frk, and Src42A form a distinct family of intracellular Src-like tyrosine kinases". Oncol. Res. 13 (6–10): 409–19. doi:10.3727/096504003108748438. PMID 12725532.
Craven RJ, Cance WG, Liu ET (1995). "The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb". Cancer Res. 55 (18): 3969–72. PMID 7664264.
Cance WG, Craven RJ, Bergman M, et al. (1995). "Rak, a novel nuclear tyrosine kinase expressed in epithelial cells". Cell Growth Differ. 5 (12): 1347–55. PMID 7696183.
Cance WG, Craven RJ, Weiner TM, Liu ET (1993). "Novel protein kinases expressed in human breast cancer". Int. J. Cancer. 54 (4): 571–7. doi:10.1002/ijc.2910540409. PMID 8099900.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Meyer T, Xu L, Chang J, et al. (2003). "Breast cancer cell line proliferation blocked by the Src-related Rak tyrosine kinase". Int. J. Cancer. 104 (2): 139–46. doi:10.1002/ijc.10925. PMID 12569567.
Watanabe T, Ohnuma T, Shibata N, et al. (2004). "No genetic association between Fyn kinase gene polymorphisms (-93A/G, IVS10+37T/C and Ex12+894T/G) and Japanese sporadic Alzheimer's disease". Neurosci. Lett. 360 (1–2): 109–11. doi:10.1016/j.neulet.2004.02.046. PMID 15082191.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000111816 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019779 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7510261-5] Lee J, Wang Z, Luoh SM, Wood WI, Scadden DT (April 1994). "Cloning of FRK, a novel human intracellular SRC-like tyrosine kinase-encoding gene". Gene. 138 (1–2): 247–51. doi:10.1016/0378-1119(94)90817-6. PMID 7510261.

[entrez-6] "Entrez Gene: FRK fyn-related kinase".

[pmid7664264-7] Craven, R J; Cance W G; Liu E T (September 1995). "The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb". Cancer Res. UNITED STATES. 55 (18): 3969–72. ISSN 0008-5472. PMID 7664264.

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Fyn-related kinase

Interactions

References

Further reading