IGFBP2

Insulin-like growth factor-binding protein 2 is a protein that in humans is encoded by the IGFBP2 gene.[5]

IGFBP2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIGFBP2, IBP2, IGF-BP53, insulin like growth factor binding protein 2
External IDsOMIM: 146731 MGI: 96437 HomoloGene: 499 GeneCards: IGFBP2
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q35Start216,632,828 bp[1]
End216,664,436 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

3485

16008

Ensembl

ENSG00000115457

ENSMUSG00000039323

UniProt

P18065

P47877

RefSeq (mRNA)

NM_001313990
NM_001313992
NM_001313993
NM_000597

NM_008342
NM_001310659

RefSeq (protein)

NP_000588
NP_001300919
NP_001300921
NP_001300922

NP_001297588
NP_032368

Location (UCSC)Chr 2: 216.63 – 216.66 MbChr 1: 72.82 – 72.85 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References
  1. GRCh38: Ensembl release 89: ENSG00000115457 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000039323 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Zapf J, Kiefer M, Merryweather J, Musiarz F, Bauer D, Born W, Fischer JA, Froesch ER (Oct 1990). "Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia". J Biol Chem. 265 (25): 14892–8. PMID 1697583.

Further reading
  • Rajaram S, Baylink DJ, Mohan S (1997). "Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions". Endocr. Rev. 18 (6): 801–31. doi:10.1210/er.18.6.801. PMID 9408744.
  • Wolf E, Lahm H, Wu M, et al. (2000). "Effects of IGFBP-2 overexpression in vitro and in vivo". Pediatr. Nephrol. 14 (7): 572–8. doi:10.1007/s004670000362. PMID 10912521.
  • Chesik D, De Keyser J, Wilczak N (2007). "Insulin-like growth factor binding protein-2 as a regulator of IGF actions in CNS: implications in multiple sclerosis". Cytokine Growth Factor Rev. 18 (3–4): 267–78. doi:10.1016/j.cytogfr.2007.04.001. PMID 17485236.
  • Binkert C, Margot JB, Landwehr J, et al. (1992). "Structure of the human insulin-like growth factor binding protein-2 gene". Mol. Endocrinol. 6 (5): 826–36. doi:10.1210/me.6.5.826. PMID 1376411.
  • Zhou J, Bondy C (1992). "Insulin-like growth factor-II and its binding proteins in placental development". Endocrinology. 131 (3): 1230–40. doi:10.1210/en.131.3.1230. PMID 1380437.
  • Ehrenborg E, Vilhelmsdotter S, Bajalica S, et al. (1991). "Structure and localization of the human insulin-like growth factor-binding protein 2 gene". Biochem. Biophys. Res. Commun. 176 (3): 1250–5. doi:10.1016/0006-291X(91)90420-C. PMID 1710112.
  • Agarwal N, Hsieh CL, Sills D, et al. (1991). "Sequence analysis, expression and chromosomal localization of a gene, isolated from a subtracted human retina cDNA library, that encodes an insulin-like growth factor binding protein (IGFBP2)". Exp. Eye Res. 52 (5): 549–61. doi:10.1016/0014-4835(91)90056-K. PMID 1712312.
  • Roghani M, Lassarre C, Zapf J, et al. (1991). "Two insulin-like growth factor (IGF)-binding proteins are responsible for the selective affinity for IGF-II of cerebrospinal fluid binding proteins". J. Clin. Endocrinol. Metab. 73 (3): 658–66. doi:10.1210/jcem-73-3-658. PMID 1714916.
  • Clemmons DR, Snyder DK, Busby WH (1991). "Variables controlling the secretion of insulin-like growth factor binding protein-2 in normal human subjects". J. Clin. Endocrinol. Metab. 73 (4): 727–33. doi:10.1210/jcem-73-4-727. PMID 1716260.
  • Roghani M, Segovia B, Whitechurch O, Binoux M (1993). "Purification from human cerebrospinal fluid of insulin-like growth factor binding proteins (IGFBPs). Isolation of IGFBP-2, an altered form of IGFBP-3 and a new IGFBP species". Growth Regul. 1 (3): 125–30. PMID 1726837.
  • Rosenfeld RG, Pham H, Conover CA, et al. (1989). "Structural and immunological comparison of insulin-like growth factor binding proteins of cerebrospinal and amniotic fluids". J. Clin. Endocrinol. Metab. 68 (3): 638–46. doi:10.1210/jcem-68-3-638. PMID 2465304.
  • Binkert C, Landwehr J, Mary JL, et al. (1989). "Cloning, sequence analysis and expression of a cDNA encoding a novel insulin-like growth factor binding protein (IGFBP-2)". EMBO J. 8 (9): 2497–502. PMC 401241. PMID 2479552.
  • Ilvesmäki V, Blum WF, Voutilainen R (1994). "Insulin-like growth factor binding proteins in the human adrenal gland". Mol. Cell. Endocrinol. 97 (1–2): 71–9. doi:10.1016/0303-7207(93)90212-3. PMID 7511544.
  • Zhou J, Bondy C (1993). "Anatomy of the human ovarian insulin-like growth factor system". Biol. Reprod. 48 (3): 467–82. doi:10.1095/biolreprod48.3.467. PMID 7680905.
  • Han VK, Bassett N, Walton J, Challis JR (1996). "The expression of insulin-like growth factor (IGF) and IGF-binding protein (IGFBP) genes in the human placenta and membranes: evidence for IGF-IGFBP interactions at the feto-maternal interface". J. Clin. Endocrinol. Metab. 81 (7): 2680–93. doi:10.1210/jc.81.7.2680. PMID 8675597.
  • Bach LA, Rechler MM (1996). "Measurement of insulin-like growth factor (IGF)-II binding to purified IGF binding proteins 1-6: comparison of charcoal adsorption and high performance size exclusion chromatography". Biochim. Biophys. Acta. 1313 (1): 79–88. doi:10.1016/0167-4889(96)00053-5. PMID 8781553.
  • Ho PJ, Baxter RC (1997). "Insulin-like growth factor-binding protein-2 in patients with prostate carcinoma and benign prostatic hyperplasia". Clin. Endocrinol. 46 (3): 333–42. doi:10.1046/j.1365-2265.1997.1100922.x. PMID 9156044.
  • Wong MS, Fong CC, Yang M (1999). "Biosensor measurement of the interaction kinetics between insulin-like growth factors and their binding proteins". Biochim. Biophys. Acta. 1432 (2): 293–301. doi:10.1016/S0167-4838(99)00106-5. PMID 10407151.
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