Zinc transporter protein

Zinc transporter proteins (Zrt), or simply zinc transporters, are membrane transport proteins of the solute carrier family which control the membrane transport of zinc and regulate its intracellular and cytoplasmic concentrations.[1] They include two major groups: (1) the zinc transporter (ZnT) or solute carrier 30 (SLC30) family, which controls the efflux of zinc from the cytoplasm out of the cell and from the cytoplasm into vesicles; and (2) the zinc importer, Zrt- and Irt-like protein (ZIP), or solute carrier 39A (SLC39A) family, which controls the influx of zinc into the cytoplasm from outside the cell and from vesicles.[1]

At least one zinc transporter, ZIP9, is also a G protein-coupled receptor and membrane androgen receptor.[2]

Families

ZnT (SLC30)

ZnT1, ZnT2, ZnT3, ZnT4, ZnT5, ZnT6, ZnT7, ZnT8, ZnT9, ZnT10

ZntB Zinc Transporter Protein

Unlike some other zinc transporter proteins, the mechanism of how Zn2+ is transported via ZntB is not well understood. However, scientists have been able to speculate that the transport of Zn2+ is related to pH gradient and the electrostatics of the protein membrane.[3][4]

ZntB Transporter Protein Structure: The left side of the image shows the full-length ZntB protein structure, without the presence of zinc. The right side shows the cytoplasmic domain of the protein and the apparent conformation change undergone by the protein to accommodate zinc transport. The conformation change is believed to be necessary for zinc ion transport. The chlorine ions (illustrated as the orange circles) support the conclusion that a change in the electrostatics and pH are necessary for transport.[3] [4]

ZIP (SLC39A)

ZIP1, ZIP2, ZIP3, ZIP4, ZIP5, ZIP6, ZIP7, ZIP8, ZIP9, ZIP10, ZIP11, ZIP12, ZIP13, ZIP14

References

  1. 1 2 Hara T, Takeda TA, Takagishi T, Fukue K, Kambe T, Fukada T (2017). "Physiological roles of zinc transporters: molecular and genetic importance in zinc homeostasis". J Physiol Sci. 67 (2): 283–301. doi:10.1007/s12576-017-0521-4. PMID 28130681.
  2. ↑ Thomas P, Converse A, Berg HA (2017). "ZIP9, a novel membrane androgen receptor and zinc transporter protein". Gen. Comp. Endocrinol. doi:10.1016/j.ygcen.2017.04.016. PMID 28479083.
  3. 1 2 Gati, Cornelius; Stetsenko, Artem; Slotboom, Dirk J.; Scheres, Sjors H. W.; Guskov, Albert (2017-11-03). "The structural basis of proton driven zinc transport by ZntB". Nature Communications. 8 (1). doi:10.1038/s41467-017-01483-7. ISSN 2041-1723.
  4. 1 2 Tan, Kemin; Sather, Alicia; Robertson, Janice L.; Moy, Shiu; Roux, Benoît; Joachimiak, Andrzej (2009-10-01). "Structure and electrostatic property of cytoplasmic domain of ZntB transporter". Protein Science. 18 (10): 2043–2052. doi:10.1002/pro.215. ISSN 1469-896X. PMC 2786968.


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