Small nucleolar RNA Z195/SNORD33 family

Small nucleolar RNA Z195/SNORD33/SNORD32 family
Identifiers
Symbol SNORD33
Alt. Symbols snoZ195
Rfam RF00133
Other data
RNA type Gene; snRNA; snoRNA; C/D-box
Domain(s) Eukaryota
GO 0006396 0005730
SO 0000593
PDB structures PDBe

Small nucleolar RNA Z195/SNORD33 (also known as U33) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

snoRNA Z195/SNORD33 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1]

Plant snoRNA Z195 was identified in a screen of Arabidopsis thaliana.[2]

An experiment that looked at 22 different non-small-cell lung cancer tissues found that SNORD33, SNORD66 and SNORD76 were over-expressed relative to matched noncancerous lung tissues.[3]

References

  1. ↑ Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology. 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
  2. ↑ Marker, C.; Zemann, A.; Terhörst, T.; Kiefmann, M.; Kastenmayer, J. P.; Green, P.; Bachellerie, J. P.; Brosius, J. R.; Hüttenhofer, A. (10 December 2002). "Experimental RNomics: identification of 140 candidates for small non-messenger RNAs in the plant Arabidopsis thaliana". Current Biology. 12 (23): 2002–2013. doi:10.1016/S0960-9822(02)01304-0. PMID 12477388.
  3. ↑ Liao, Jipei; Yu, Lei; Mei, Yuping; Guarnera, Maria; Shen, Jun; Li, Ruiyun; Liu, Zhenqiu; Jiang, Feng (2010). "Small nucleolar RNA signatures as biomarkers for non-small-cell lung cancer". Molecular Cancer. 9: 198. doi:10.1186/1476-4598-9-198. PMC 2919450. PMID 20663213.


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