Small nucleolar RNA SNORD62

Small nucleolar RNA SNORD62
Identifiers
Symbol SNORD62
Alt. Symbols U62
Rfam RF00153
Other data
RNA type Gene; snRNA; snoRNA; C/D-box
Domain(s) Eukaryota
GO 0006396 0005730
SO 0000593
PDB structures PDBe

snoRNA U62 (also known as SNORD62) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

snoRNA U62 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1]

In the human genome there are two identical copies of snoRNA U62 (called U62A and U62B) both of which are located within the introns of the same host gene which encodes a hypothetical protein (KIAA0515).[2] U62 is predicted to guide the 2'O-ribose methylation of 18S ribosomal RNA (rRNA) reside A590.[3]

References

  1. ↑ Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology. 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
  2. ↑ Tycowski, Kazimierz T.; Smith, Christine M.; Shu, Mei-Di; Steitz, Joan A. (December 10, 1996). "A small nucleolar RNA requirement for site-specific ribose methylation of rRNA in Xenopus". Proceedings of the National Academy of Sciences. 93 (25): 14480–14485. doi:10.1073/pnas.93.25.14480. PMC 26158. PMID 8962077.
  3. ↑ Lestrade, Laurent; Weber, Michel J. (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research. 34 (Supplement 1: Database Issue): D158–D162. CiteSeerX 10.1.1.105.7552. doi:10.1093/nar/gkj002. PMC 1347365. PMID 16381836.


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