Small nucleolar RNA MBI-28

Small nucleolar RNA SNORA3/SNORA45 family
Identifiers
Symbol SNORA3
Alt. Symbols snoMBI-28
Rfam RF00334
Other data
RNA type Gene; snRNA; snoRNA; H/ACA-box
Domain(s) Eukaryota
GO 0006396 0005730
SO 0000594
PDB structures PDBe

Small nucleolar RNA MBI-28, also known as SNORA3 and ACA3, is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a 'guide RNA'.[1]

snoRNA MBI-28 was originally cloned from mouse brain tissues[2] and belongs to the H/ACA box class of snoRNAs as it has the predicted hairpin-hinge-hairpin-tail structure and has the conserved H/ACA-box motifs.

References

  1. ↑ Kiss, Tamás (2002). "Small Nucleolar RNAs". Cell. 109 (2): 145–148. doi:10.1016/S0092-8674(02)00718-3. PMID 12007400.
  2. ↑ Huttenhofer, Alexander; Kiefmann, Martin; Meier-Ewert, Sebastian; O'Brien, John; Lehrach, Hans; Bachellerie, Jean-Pierre; Brosius, Jürgen (1 June 2001). "RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse". The EMBO Journal. 20 (11): 2943–2953. doi:10.1093/emboj/20.11.2943. PMC 125495. PMID 11387227.


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