Small nucleolar RNA TBR5

Small nucleolar RNA TBR5
Identifiers
Symbol snoTBR5
Rfam RF00292
Other data
RNA type Gene; snRNA; snoRNA; CD-box
Domain(s) Eukaryota
GO 0006396 0005730
SO 0000593
PDB structures PDBe

TBR5 is a member of the C/D class of snoRNA which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1][2]

Together with TBR7 and TBR17 it is a part of a tandemly repeated snoRNA gene cluster, located within the spliced leader RNA (SLA).[3] The cluster genes are produced as polycistronic RNA.[4]

See also

Small nucleolar RNA TBR2

References

  1. ↑ Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology. 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
  2. ↑ Dunbar, DA; Wormsley S; Lowe TM; Baserga SJ (2000). "Fibrillarin-associated box C/D small nucleolar RNAs in Trypanosoma brucei. Sequence conservation and implications for 2'-O-ribose methylation of rRNA". J Biol Chem. 275 (19): 14767&ndash, 14776. doi:10.1074/jbc.M001180200. PMID 10747997.
  3. ↑ Roberts, T. G.; Sturm, N. R.; Yee, B. K.; Yu, M. C.; Hartshorne, T.; Agabian, N.; Campbell, D. A. (August 1998). "Three small nucleolar RNAs identified from the spliced leader-associated RNA locus in kinetoplastid protozoans". Molecular and Cellular Biology. 18 (8): 4409–4417. doi:10.1128/mcb.18.8.4409. ISSN 0270-7306. PMC 109026. PMID 9671450.
  4. ↑ Dunbar, D. A.; Chen, A. A.; Wormsley, S.; Baserga, S. J. (2000-08-01). "The genes for small nucleolar RNAs in Trypanosoma brucei are organized in clusters and are transcribed as a polycistronic RNA". Nucleic Acids Research. 28 (15): 2855–2861. doi:10.1093/nar/28.15.2855. ISSN 1362-4962. PMC 102681. PMID 10908346.


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