Small nucleolar RNA U6-53/MBII-28

Small nucleolar RNA U6-53/MBII-28
Predicted secondary structure and sequence conservation of snoU6-53
Identifiers
Symbol snoU6-53
Rfam RF00377
Other data
RNA type Gene; snRNA; snoRNA; C/D-box
Domain(s) Eukaryota
GO 0006396 0005730
SO 0000593
PDB structures PDBe

Small nucleolar RNA U6-53 (also known as MBII-28) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

snoRNA U6-53 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1][2]

This snoRNA possesses sequence complementarity to U6 spliceosomal RNA and is likely to direct its 2'-O-methylation.[3]

References

  1. ↑ Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology. 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
  2. ↑ Kiss, Tamás (2002). "Small Nucleolar RNAs". Cell. 109 (2): 145–148. doi:10.1016/S0092-8674(02)00718-3. PMID 12007400.
  3. ↑ Ganot, Philippe; Jády, Beáta E.; Bortolin, Marie-Line; Darzacq, Xavier; Kiss, Tamás (October 1999). "Nucleolar factors direct the 2'-O-ribose methylation and pseudouridylation of U6 spliceosomal RNA". Molecular and Cellular Biology. 19 (10): 6906–6917. doi:10.1128/mcb.19.10.6906. PMC 84686. PMID 10490628.


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