SLC7A5

SLC7A5
Identifiers
AliasesSLC7A5, 4F2LC, CD98, D16S469E, E16, LAT1, MPE16, hLAT1, solute carrier family 7 member 5
External IDsMGI: 1298205 HomoloGene: 55759 GeneCards: SLC7A5
Gene location (Human)
Chr.Chromosome 16 (human)[1]
Band16q24.2Start87,830,023 bp[1]
End87,869,488 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

8140

20539

Ensembl

ENSG00000103257

ENSMUSG00000040010

UniProt

Q01650

Q9Z127

RefSeq (mRNA)

NM_003486

NM_011404

RefSeq (protein)

NP_003477

NP_035534

Location (UCSC)Chr 16: 87.83 – 87.87 MbChr 8: 121.88 – 121.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Solute carrier family 7 member 5 also known as large neutral amino acids transporter small subunit 1 is a protein that in humans is encoded by the SLC7A5 gene.[5]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000103257 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040010 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: solute carrier family 7 (cationic amino acid transporter".

Further reading

  • Kaira K, Oriuchi N, Imai H, et al. (2009). "Prognostic significance of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in stage I pulmonary adenocarcinoma". Lung Cancer. 66 (1): 120–6. doi:10.1016/j.lungcan.2008.12.015. PMID 19171406.
  • Verrey F, Jack DL, Paulsen IT, et al. (1999). "New glycoprotein-associated amino acid transporters". J. Membr. Biol. 172 (3): 181–92. doi:10.1007/s002329900595. PMID 10568788.
  • Nawashiro H, Otani N, Shinomiya N, et al. (2006). "L-type amino acid transporter 1 as a potential molecular target in human astrocytic tumors". Int. J. Cancer. 119 (3): 484–92. doi:10.1002/ijc.21866. PMID 16496379.
  • Nawashiro H, Otani N, Uozumi Y, et al. (2005). "High expression of L-type amino acid transporter 1 in infiltrating glioma cells". Brain Tumor Pathol. 22 (2): 89–91. doi:10.1007/s10014-005-0188-z. PMID 18095110.
  • Ohno Y, Suda K, Masuko K, et al. (2008). "Production and characterization of highly tumor-specific rat monoclonal antibodies recognizing the extracellular domain of human L-type amino-acid transporter 1". Cancer Sci. 99 (5): 1000–7. doi:10.1111/j.1349-7006.2008.00770.x. PMID 18294274.
  • Vumma R, Wiesel FA, Flyckt L, et al. (2008). "Functional characterization of tyrosine transport in fibroblast cells from healthy controls". Neurosci. Lett. 434 (1): 56–60. doi:10.1016/j.neulet.2008.01.028. PMID 18262359.
  • Endou H, Kanai Y (1999). "[Amino acid transporter molecule as a drug target]". Nippon Yakurigaku Zasshi. 114 Suppl 1: 11P–16P. PMID 10629848.
  • Nakanishi K, Ogata S, Matsuo H, et al. (2007). "Expression of LAT1 predicts risk of progression of transitional cell carcinoma of the upper urinary tract". Virchows Arch. 451 (3): 681–90. doi:10.1007/s00428-007-0457-9. PMID 17622555.
  • Kaira K, Oriuchi N, Imai H, et al. (2009). "L-type amino acid transporter 1 (LAT1) is frequently expressed in thymic carcinomas but is absent in thymomas". J Surg Oncol. 99 (7): 433–8. doi:10.1002/jso.21277. PMID 19347882.
  • Anderson BM, Schnetz-Boutaud NC, Bartlett J, et al. (2009). "Examination of association of genes in the serotonin system to autism". Neurogenetics. 10 (3): 209–16. doi:10.1007/s10048-009-0171-7. PMC 2753863. PMID 19184136.
  • Ring BZ, Seitz RS, Beck RA, et al. (2009). "A novel five-antibody immunohistochemical test for subclassification of lung carcinoma". Mod. Pathol. 22 (8): 1032–43. doi:10.1038/modpathol.2009.60. PMID 19430419.
  • Kaira K, Oriuchi N, Imai H, et al. (2008). "Expression of L-type amino acid transporter 1 (LAT1) in neuroendocrine tumors of the lung". Pathol. Res. Pract. 204 (8): 553–61. doi:10.1016/j.prp.2008.02.003. PMID 18440724.
  • Kobayashi K, Ohnishi A, Promsuk J, et al. (2008). "Enhanced tumor growth elicited by L-type amino acid transporter 1 in human malignant glioma cells". Neurosurgery. 62 (2): 493–503, discussion 503-4. doi:10.1227/01.neu.0000316018.51292.19. PMID 18382329.
  • Kühne A, Kaiser R, Schirmer M, et al. (2007). "Genetic polymorphisms in the amino acid transporters LAT1 and LAT2 in relation to the pharmacokinetics and side effects of melphalan". Pharmacogenet. Genomics. 17 (7): 505–17. doi:10.1097/FPC.0b013e3280ea77cd. PMID 17558306.
  • Kaira K, Oriuchi N, Imai H, et al. (2008). "Prognostic significance of L-type amino acid transporter 1 expression in resectable stage I-III nonsmall cell lung cancer". Br. J. Cancer. 98 (4): 742–8. doi:10.1038/sj.bjc.6604235. PMC 2259171. PMID 18253116.
  • Bröer S (2008). "Amino acid transport across mammalian intestinal and renal epithelia". Physiol. Rev. 88 (1): 249–86. doi:10.1152/physrev.00018.2006. PMID 18195088.
  • Kaira K, Oriuchi N, Imai H, et al. (2008). "l-type amino acid transporter 1 and CD98 expression in primary and metastatic sites of human neoplasms". Cancer Sci. 99 (12): 2380–6. doi:10.1111/j.1349-7006.2008.00969.x. PMID 19018776.
  • Imai H, Kaira K, Oriuchi N, et al. (2009). "L-type amino acid transporter 1 expression is a prognostic marker in patients with surgically resected stage I non-small cell lung cancer". Histopathology. 54 (7): 804–13. doi:10.1111/j.1365-2559.2009.03300.x. PMID 19635099.
  • Shennan DB, Thomson J (2008). "Inhibition of system L (LAT1/CD98hc) reduces the growth of cultured human breast cancer cells". Oncol. Rep. 20 (4): 885–9. doi:10.3892/or_00000087. PMID 18813831.
  • Sakata T, Ferdous G, Tsuruta T, et al. (2009). "L-type amino-acid transporter 1 as a novel biomarker for high-grade malignancy in prostate cancer". Pathol. Int. 59 (1): 7–18. doi:10.1111/j.1440-1827.2008.02319.x. PMID 19121087.


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