Otenabant

Otenabant
Clinical data
ATC code	none;
Identifiers
	IUPAC name 1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-(ethylamino)piperidine-4- carboxamide;
CAS Number	686344-29-6 ;
PubChem CID	10052040;
ChemSpider	8227602 ;
UNII	J8211Y53EF;
KEGG	D09362 ;
ChEMBL	CHEMBL562668 ;
Chemical and physical data
Formula	C25H25Cl2N7O
Molar mass	510.4 g/mol
3D model (JSmol)	Interactive image;
	SMILES CCNC1(CCN(CC1)C2=NC=NC3=C2N=C(N3C4=CC=C(C=C4)Cl)C5=CC=CC=C5Cl)C(=O)N;
	InChI InChI=1S/C25H25Cl2N7O/c1-2-31-25(24(28)35)11-13-33(14-12-25)22-20-23(30-15-29-22)34(17-9-7-16(26)8-10-17)21(32-20)18-5-3-4-6-19(18)27/h3-10,15,31H,2,11-14H2,1H3,(H2,28,35) ; Key:UNAZAADNBYXMIV-UHFFFAOYSA-N ;
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Otenabant (CP-945,598) is a drug which acts as a potent and highly selective CB₁ antagonist.^[1] It was developed by Pfizer for the treatment of obesity,^[2] but development for this application has been discontinued following the problems seen during clinical use of the similar drug rimonabant.^[3]

References

↑ Kim, M.; et al. (2008), "Design, chemical synthesis, and biological evaluation of novel triazolyl analogues of taranabant (MK-0364), a cannabinoid-1 receptor inverse agonist" (PDF), Tetrahedron, 64 (48): 10802–10809, doi:10.1016/j.tet.2008.09.057
↑ Woods SC. The endocannabinoid system: novel pathway for cardiometabolic Risk-factor reduction. Journal of the American Academy of Physician Assistants. 2007 Nov;Suppl Endocannabinoid:7-10. PMID 18047036
↑ http://www.pfizer.com

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[Kim_2008-1] Kim, M.; et al. (2008), "Design, chemical synthesis, and biological evaluation of novel triazolyl analogues of taranabant (MK-0364), a cannabinoid-1 receptor inverse agonist" (PDF), Tetrahedron, 64 (48): 10802–10809, doi:10.1016/j.tet.2008.09.057

[2] Woods SC. The endocannabinoid system: novel pathway for cardiometabolic Risk-factor reduction. Journal of the American Academy of Physician Assistants. 2007 Nov;Suppl Endocannabinoid:7-10. PMID 18047036

[3] ttp://www.pfizer.com

Clinical data

ATC code	none
Identifiers
IUPAC name 1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-(ethylamino)piperidine-4- carboxamide
CAS Number	686344-29-6^Y
PubChem CID	10052040
ChemSpider	8227602^N
UNII	J8211Y53EF
KEGG	D09362^Y
ChEMBL	CHEMBL562668^N
Chemical and physical data
Formula	C₂₅H₂₅Cl₂N₇O
Molar mass	510.4 g/mol
3D model (JSmol)	Interactive image
SMILES CCNC1(CCN(CC1)C2=NC=NC3=C2N=C(N3C4=CC=C(C=C4)Cl)C5=CC=CC=C5Cl)C(=O)N
InChI InChI=1S/C25H25Cl2N7O/c1-2-31-25(24(28)35)11-13-33(14-12-25)22-20-23(30-15-29-22)34(17-9-7-16(26)8-10-17)21(32-20)18-5-3-4-6-19(18)27/h3-10,15,31H,2,11-14H2,1H3,(H2,28,35)^N Key:UNAZAADNBYXMIV-UHFFFAOYSA-N^N
^NY (what is this?) (verify)

Otenabant

See also

References