ABHD12

ABHD12
Identifiers
AliasesABHD12, ABHD12A, BEM46L2, C20orf22, PHARC, dJ965G21.2, abhydrolase domain containing 12
External IDsMGI: 1923442 HomoloGene: 22910 GeneCards: ABHD12
Gene location (Human)
Chr.Chromosome 20 (human)[1]
Band20p11.21Start25,294,743 bp[1]
End25,390,983 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

26090

76192

Ensembl

ENSG00000100997

ENSMUSG00000032046

UniProt

Q8N2K0

Q99LR1

RefSeq (mRNA)

NM_001042472
NM_015600

NM_024465
NM_001356549
NM_001356550

RefSeq (protein)

NP_001035937
NP_056415

NP_077785
NP_001343478
NP_001343479

Location (UCSC)Chr 20: 25.29 – 25.39 MbChr 2: 150.83 – 150.9 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

alpha/beta-Hydrolase domain containing 12 (ABHD12) is a serine hydrolase encoded by the ABHD12 gene that participates in the breakdown of the endocannabinoid neurotransmitter 2-arachidonylglycerol (2-AG) in the central nervous system.[5] It is responsible for about 9% of brain 2-AG hydrolysis.[5] Together, ABHD12 along with two other enzymes, monoacylglycerol lipase (MAGL) and ABHD6, control 99% of 2-AG hydrolysis in the brain.[5][6] ABHD12 also serves as a lysophospholipase and metabolizes lysophosphatidylserine (LPS).[7]

Inhibitors

Inhibitors of ABHD12 have been identified.[7] Orlistat (tetrahydrolipstatin; THL) and methyl arachidonyl fluorophosphonate (MAFP), so-called "universal lipase/serine hydrolase inhibitors" that are extremely non-selective enzyme inhibitors, were found to inhibit ABHD12.[7] Selective reversible inhibitors have also been identified, including betulinic acid, maslinic acid, oleanolic acid, and ursolic acid.[7]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000100997 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032046 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 3 Cannabinoid Receptors—Advances in Research and Application: 2012 Edition: ScholarlyBrief. ScholarlyEditions. 26 December 2012. pp. 68–. ISBN 978-1-4816-0672-1.
  6. ↑ Savinainen JR, Saario SM, Laitinen JT (February 2012). "The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors". Acta Physiol (Oxf). 204 (2): 267–76. doi:10.1111/j.1748-1716.2011.02280.x. PMC 3320662. PMID 21418147.
  7. 1 2 3 4 Bogyo, Matthew; Parkkari, Teija; Haavikko, Raisa; Laitinen, Tuomo; Navia-Paldanius, Dina; Rytilahti, Roosa; Vaara, Miia; Lehtonen, Marko; Alakurtti, Sami; Yli-Kauhaluoma, Jari; Nevalainen, Tapio; Savinainen, Juha R.; Laitinen, Jarmo T. (2014). "Discovery of Triterpenoids as Reversible Inhibitors of α/β-hydrolase Domain Containing 12 (ABHD12)". PLoS ONE. 9 (5): e98286. doi:10.1371/journal.pone.0098286. ISSN 1932-6203. PMC 4045134. PMID 24879289.


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