List of cytochrome P450 modulators

This is a list of cytochrome P450 modulators, or inhibitors and inducers of cytochrome P450 enzymes.

Enzyme	Inhibitors	Inducers
CYP1A1	Certain foods (e.g., cumin, turmeric) Certain herbs/herbal teas (e.g., peppermint, German chamomile, dandelion) Amiodarone Caffeine Cimetidine Echinacea Fluoroquinolones (e.g., ciprofloxacin) Fluvoxamine Interferon Isoniazid Methoxsalen Mibefradil Naringenin (grapefruit) Nilutamide St. John's wort Verapamil	Certain foods (e.g., broccoli, cauliflower, brussels sprouts, chargrilled meat) Insulin Methylcholanthrene Modafinil Nafcillin Omeprazole Phenytoin beta-Naphthoflavone Tobacco
CYP2A6	Amiodarone Amlodipine Buprenorphine Clofibrate Clotrimazole Desipramine Disulfiram Entacapone Fenofibrate Flavonoids (grapefruit) Gabapentin Isoniazid Ketoconazole Letrozole Methimazole Methoxsalen Metyrapone Miconazole Modafinil Nicotine Orphenadrine Pilocarpine Pregabalin Selegiline Sulconazole Tioconazole Tranylcypromine	Barbiturates (e.g., amobarbital, pentobarbital, phenobarbital, secobarbital) Rifampicin
CYP2B6	Curcumin (turmeric) Memantine Orphenadrine ThioTEPA Ticlopidine	Carbamazepine Phenobarbital Phenytoin Rifampicin
CYP2C8	Gemfibrozil Montelukast Quercetin Thiazolidinediones Trimethoprim	Rifampicin
CYP2C9	Amiodarone Apigenin Chloramphenicol Cimetidine Cyclizine Fenofibrate Flavonoids (e.g., amentoflavone (Ginkgo biloba, St. John’s Wort)) Fluconazole Fluvastatin Fluvoxamine Isoniazid Lovastatin Miconazole Modafinil Nilutamide Phenylbutazone Probenecid Promethazine Quercetin Sertraline Sulfamethoxazole Sulfaphenazole Teniposide Valproic acid Voriconazole Zafirlukast	Aprepitant Bosentan Enzalutamide Phenobarbital Phenytoin Rifampicin Secobarbital St. Johns Wort
CYP2C19	Chloramphenicol Cimetidine Felbamate Fluoxetine Fluvoxamine Indomethacin Isoniazid JWH-018 Ketoconazole Moclobemide Modafinil Probenecid Proton pump inhibitors (e.g., lansoprazole, omeprazole, pantoprazole, rabeprazole) Ticlopidine Topiramate	Artemisinin Aspirin Carbamazepine Enzalutamide Norethisterone Phenytoin Prednisone Rifampicin
CYP2D6	Amiodarone Buprenorphine Bupropion Cannabidiol Celecoxib Chlorphenamine Chlorpromazine Cimetidine Cinacalcet Citalopram Clemastine Clomipramine Cocaine Diphenhydramine Doxepin Doxorubicin Duloxetine Escitalopram Fluoxetine Halofantrine Haloperidol Hydroxyzine Hyperforin (St. Johns Wort) Levomepromazine Methadone Methylphenidate Metoclopramide Mibefradil Midodrine Moclobemide Niacin Nicotinamide Paroxetine Perphenazine Promethazine Quinidine Risperidone Ritonavir Sertraline Terbinafine Thioridazine Ticlopidine Tripelennamine Zuclopenthixol	Dexamethasone Glutethimide Haloperidol Rifampicin
CYP2E1	Cimetidine
CYP3A4	Amiodarone Aprepitant Bergamottin (grapefruit) Buprenorphine Cafestol Chloramphenicol Cimetidine Ciprofloxacin Clarithromycin Cobicistat Delavirdine Diltiazem Dithiocarbamate Domperidone Erythromycin Fluconazole Fluvoxamine Gabapentin Gestodene Ginkgo biloba Imatinib Indinavir Isoniazid Itraconazole Ketoconazole Mibefradil Mifepristone Milk thistle Nefazodone Nelfinavir Niacinamide Nilutamide Norfloxacin Orphenadrine Piperine Quercetin Ritonavir Saquinavir Star fruit Telithromycin Valerian Valproic acid Verapamil Voriconazole	Barbiturates (e.g., butalbital, phenobarbital) Capsaicin Carbamazepine Efavirenz Enzalutamide Glucocorticoids Modafinil Nevirapine Oxcarbazepine Phenytoin Pioglitazone Quercetin Rifabutin Rifampicin St. John's wort Topiramate Troglitazone
CYP4–51	See Prostanoid signaling modulators and Leukotriene signaling modulators instead for eicosanoid-specific CYP450s, including: CYP4F3 (leukotriene-B4 ω-hydroxylase 2) CYP5A1 (thromboxane-A synthase) CYP8A1 (prostacyclin synthase)	See the list of steroid metabolism modulators instead for steroid/sterol-specific CYP450s, including: CYP7A1 (cholesterol 7α-hydroxylase) CYP7B1 (25-hydroxycholesterol 7α-hydroxylase) CYP8B1 (sterol 12α-hydroxylase) CYP11A1 (cholesterol side-chain cleavage enzyme; P450scc) CYP11B1 (steroid 11β-hydroxylase) CYP11B2 (aldosterone synthase) CYP17A1 (steroid 17α-hydroxylase/17,20-lyase) CYP19A1 (aromatase) CYP21A2 (steroid 21-hydroxylase) CYP24A1 (1,25-dihydroxyvitamin D3 24-hydroxylase) CYP27A1 (sterol 27-hydroxylase) CYP27B1 (25-hydroxyvitamin D3 1α-hydroxylase) CYP39A1 (oxysterol 7α-hydroxylase 2) CYP46A1 (cholesterol 24-hydroxylase) CYP51A1 (lanosterol 14α-demethylase)

List of cytochrome P450 modulators

See also