EPH receptor B4

EPHB4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEPHB4, Ephb4, AI042935, Htk, MDK2, Myk1, Tyro11, EPH receptor B4, HTK, MYK1, TYRO11, HFASD
External IDsMGI: 104757 HomoloGene: 20939 GeneCards: EPHB4
Gene location (Human)
Chr.Chromosome 7 (human)[1]
Band7q22.1Start100,802,565 bp[1]
End100,827,521 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

2050

13846

Ensembl

ENSG00000196411

ENSMUSG00000029710

UniProt

P54760

P54761

RefSeq (mRNA)

NM_004444

NM_001159571
NM_010144

RefSeq (protein)

NP_004435

NP_001153043
NP_034274

Location (UCSC)Chr 7: 100.8 – 100.83 MbChr 5: 137.35 – 137.38 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ephrin type-B receptor 4 is a protein that in humans is encoded by the EPHB4 gene.[5][6]

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development.[6][7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000196411 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029710 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Bennett BD, Wang Z, Kuang WJ, Wang A, Groopman JE, Goeddel DV, Scadden DT (Jun 1994). "Cloning and characterization of HTK, a novel transmembrane tyrosine kinase of the EPH subfamily". J Biol Chem. 269 (19): 14211–8. PMID 8188704.
  6. 1 2 "Entrez Gene: EPHB4 EPH receptor B4".
  7. ↑ Gerety SS, Wang HU, Chen ZF, Anderson DJ (1999). "Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development". Mol. Cell. 4 (3): 403–14. doi:10.1016/S1097-2765(00)80342-1. PMID 10518221.

Further reading

  • Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development". Annu. Rev. Neurosci. 21: 309–45. doi:10.1146/annurev.neuro.21.1.309. PMID 9530499.
  • Zhou R (1998). "The Eph family receptors and ligands". Pharmacol. Ther. 77 (3): 151–81. doi:10.1016/S0163-7258(97)00112-5. PMID 9576626.
  • Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis". Development. 126 (10): 2033–44. PMID 10207129.
  • Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly". Int. Rev. Cytol. 196: 177–244. doi:10.1016/S0074-7696(00)96005-4. PMID 10730216.
  • Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning". Philos. Trans. R. Soc. Lond. B Biol. Sci. 355 (1399): 993–1002. doi:10.1098/rstb.2000.0635. PMC 1692797. PMID 11128993.
  • Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development". Nat. Rev. Neurosci. 2 (3): 155–64. doi:10.1038/35058515. PMID 11256076.
  • Andres AC, Reid HH, Zürcher G, et al. (1994). "Expression of two novel eph-related receptor protein tyrosine kinases in mammary gland development and carcinogenesis". Oncogene. 9 (5): 1461–7. PMID 8152808.
  • Berclaz G, Andres AC, Albrecht D, et al. (1996). "Expression of the receptor protein tyrosine kinase myk-1/htk in normal and malignant mammary epithelium". Biochem. Biophys. Res. Commun. 226 (3): 869–75. doi:10.1006/bbrc.1996.1442. PMID 8831703.
  • Ephnomenclaturecommittee (1997). "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee". Cell. 90 (3): 403–4. doi:10.1016/S0092-8674(00)80500-0. PMID 9267020.
  • Nikolova Z, Djonov V, Zuercher G, et al. (1998). "Cell-type specific and estrogen dependent expression of the receptor tyrosine kinase EphB4 and its ligand ephrin-B2 during mammary gland morphogenesis". J. Cell Sci. 111 (18): 2741–51. PMID 9718367.
  • Tang XX, Brodeur GM, Campling BG, Ikegaki N (1999). "Coexpression of transcripts encoding EPHB receptor protein tyrosine kinases and their ephrin-B ligands in human small cell lung carcinoma". Clin. Cancer Res. 5 (2): 455–60. PMID 10037197.
  • Dalva MB, Takasu MA, Lin MZ, et al. (2001). "EphB receptors interact with NMDA receptors and regulate excitatory synapse formation". Cell. 103 (6): 945–56. doi:10.1016/S0092-8674(00)00197-5. PMID 11136979.
  • Wilson MD, Riemer C, Martindale DW, et al. (2001). "Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5". Nucleic Acids Res. 29 (6): 1352–65. doi:10.1093/nar/29.6.1352. PMC 29746. PMID 11239002.


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