Fyn-related kinase

FRK
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFRK, GTK, PTK5, RAK, Fyn-related kinase, fyn related Src family tyrosine kinase
External IDsMGI: 103265 HomoloGene: 48065 GeneCards: FRK
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6q22.1Start115,931,149 bp[1]
End116,060,758 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

2444

14302

Ensembl

ENSG00000111816

ENSMUSG00000019779

UniProt

P42685

Q922K9

RefSeq (mRNA)

NM_002031

NM_001159544
NM_010237
NM_001358769

RefSeq (protein)

NP_002022

NP_001153016
NP_034367
NP_001345698

Location (UCSC)Chr 6: 115.93 – 116.06 MbChr 10: 34.48 – 34.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Fyn-related kinase (FRK, formerly tyrosine protein kinase 5) is an enzyme that in humans is encoded by the FRK gene.[5][6]

The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth.[6]

Interactions

FRK has been shown to interact with retinoblastoma protein.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000111816 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019779 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Lee J, Wang Z, Luoh SM, Wood WI, Scadden DT (April 1994). "Cloning of FRK, a novel human intracellular SRC-like tyrosine kinase-encoding gene". Gene. 138 (1–2): 247–51. doi:10.1016/0378-1119(94)90817-6. PMID 7510261.
  6. 1 2 "Entrez Gene: FRK fyn-related kinase".
  7. ↑ Craven, R J; Cance W G; Liu E T (September 1995). "The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb". Cancer Res. UNITED STATES. 55 (18): 3969–72. ISSN 0008-5472. PMID 7664264.

Further reading

  • Serfas MS, Tyner AL (2003). "Brk, Srm, Frk, and Src42A form a distinct family of intracellular Src-like tyrosine kinases". Oncol. Res. 13 (6–10): 409–19. PMID 12725532.
  • Craven RJ, Cance WG, Liu ET (1995). "The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb". Cancer Res. 55 (18): 3969–72. PMID 7664264.
  • Cance WG, Craven RJ, Bergman M, et al. (1995). "Rak, a novel nuclear tyrosine kinase expressed in epithelial cells". Cell Growth Differ. 5 (12): 1347–55. PMID 7696183.
  • Cance WG, Craven RJ, Weiner TM, Liu ET (1993). "Novel protein kinases expressed in human breast cancer". Int. J. Cancer. 54 (4): 571–7. doi:10.1002/ijc.2910540409. PMID 8099900.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Meyer T, Xu L, Chang J, et al. (2003). "Breast cancer cell line proliferation blocked by the Src-related Rak tyrosine kinase". Int. J. Cancer. 104 (2): 139–46. doi:10.1002/ijc.10925. PMID 12569567.
  • Watanabe T, Ohnuma T, Shibata N, et al. (2004). "No genetic association between Fyn kinase gene polymorphisms (-93A/G, IVS10+37T/C and Ex12+894T/G) and Japanese sporadic Alzheimer's disease". Neurosci. Lett. 360 (1–2): 109–11. doi:10.1016/j.neulet.2004.02.046. PMID 15082191.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.


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