EPHA8

EPHA8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UCV, 1X5L, 3KUL
Identifiers
Aliases	EPHA8, EEK, EK3, HEK3, EPH receptor A8
External IDs	MGI: 109378 HomoloGene: 22436 GeneCards: EPHA8
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	22,603,594 bp[1]
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)[2]
End	136,956,816 bp[2]
Gene ontology
Molecular function	• transferase activity; • nucleotide binding; • protein kinase activity; • kinase activity; • transmembrane receptor protein tyrosine kinase activity; • protein tyrosine kinase activity; • ATP binding; • ephrin receptor activity; • GPI-linked ephrin receptor activity; • receptor tyrosine kinase; • transmembrane signaling receptor activity; • transmembrane-ephrin receptor activity;
Cellular component	• integral component of membrane; • endosome; • cell projection; • early endosome membrane; • membrane; • integral component of plasma membrane; • plasma membrane; • neuron projection; • cytoplasm; • receptor complex;
Biological process	• phosphorylation; • transmembrane receptor protein tyrosine kinase signaling pathway; • nervous system development; • multicellular organism development; • protein phosphorylation; • cell adhesion; • peptidyl-tyrosine phosphorylation; • substrate-dependent cell migration; • protein autophosphorylation; • axon guidance; • neuron projection development; • regulation of cell adhesion; • regulation of cell adhesion mediated by integrin; • neuron remodeling; • positive regulation of phosphatidylinositol 3-kinase activity; • ephrin receptor signaling pathway; • positive regulation of MAPK cascade; • cellular response to follicle-stimulating hormone stimulus; • negative regulation of signal transduction; • cell differentiation; • negative regulation of apoptotic process; • positive regulation of ERK1 and ERK2 cascade;
	Sources:Amigo / QuickGO
Orthologs
	2046
	13842
	ENSG00000070886
	ENSMUSG00000028661
	P29322
	O09127
	NM_001006943; NM_020526
	NM_007939
	NP_001006944; NP_065387
	NP_031965
	Wikidata
View/Edit Human	View/Edit Mouse

Ephrin type-A receptor 8 is a protein that in humans is encoded by the EPHA8 gene.^[5]^[6]

Function

This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system.^[6]

Interactions

EPHA8 has been shown to interact with FYN.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000070886 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028661 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Chan J, Watt VM (Aug 1991). "eek and erk, new members of the eph subclass of receptor protein-tyrosine kinases". Oncogene. 6 (6): 1057–61. PMID 1648701.
1 2 "Entrez Gene: EPHA8 EPH receptor A8".
↑ Choi S, Park S (Sep 1999). "Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity". Oncogene. 18 (39): 5413–22. doi:10.1038/sj.onc.1202917. PMID 10498895.

Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development". Annu. Rev. Neurosci. 21: 309–45. doi:10.1146/annurev.neuro.21.1.309. PMID 9530499.
Holland SJ, Peles E, Pawson T, Schlessinger J (1998). "Cell-contact-dependent signalling in axon growth and guidance: Eph receptor tyrosine kinases and receptor protein tyrosine phosphatase beta". Curr. Opin. Neurobiol. 8 (1): 117–27. doi:10.1016/S0959-4388(98)80015-9. PMID 9568399.
Zhou R (1998). "The Eph family receptors and ligands". Pharmacol. Ther. 77 (3): 151–81. doi:10.1016/S0163-7258(97)00112-5. PMID 9576626.
Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis". Development. 126 (10): 2033–44. PMID 10207129.
Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly". Int. Rev. Cytol. 196: 177–244. doi:10.1016/S0074-7696(00)96005-4. PMID 10730216.
Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning". Philos. Trans. R. Soc. Lond. B Biol. Sci. 355 (1399): 993–1002. doi:10.1098/rstb.2000.0635. PMC 1692797. PMID 11128993.
Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development". Nat. Rev. Neurosci. 2 (3): 155–64. doi:10.1038/35058515. PMID 11256076.
Nakamoto T, Kain KH, Ginsberg MH (2004). "Neurobiology: New connections between integrins and axon guidance". Curr. Biol. 14 (3): R121–3. doi:10.1016/j.cub.2004.01.020. PMID 14986683.
Yamaguchi Y, Pasquale EB (2004). "Eph receptors in the adult brain". Curr. Opin. Neurobiol. 14 (3): 288–96. doi:10.1016/j.conb.2004.04.003. PMID 15194108.
Murai KK, Pasquale EB (2004). "Eph receptors, ephrins, and synaptic function". The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 10 (4): 304–14. doi:10.1177/1073858403262221. PMID 15271258.
Park S, Sánchez MP (1997). "The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands". Oncogene. 14 (5): 533–42. doi:10.1038/sj.onc.1200857. PMID 9053851.
Park S, Frisén J, Barbacid M (1997). "Aberrant axonal projections in mice lacking EphA8 (Eek) tyrosine protein kinase receptors". EMBO J. 16 (11): 3106–14. doi:10.1093/emboj/16.11.3106. PMC 1169929. PMID 9214628.
Ephnomenclaturecommittee (1997). "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee". Cell. 90 (3): 403–4. doi:10.1016/S0092-8674(00)80500-0. PMID 9267020.
Lemke G (1998). "A coherent nomenclature for Eph receptors and their ligands". Mol. Cell. Neurosci. 9 (5–6): 331–2. doi:10.1006/mcne.1997.0630. PMID 9361271.
Choi S, Park S (1999). "Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity". Oncogene. 18 (39): 5413–22. doi:10.1038/sj.onc.1202917. PMID 10498895.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000070886 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028661 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid1648701-5] Chan J, Watt VM (Aug 1991). "eek and erk, new members of the eph subclass of receptor protein-tyrosine kinases". Oncogene. 6 (6): 1057–61. PMID 1648701.

[entrez-6] 1 2 "Entrez Gene: EPHA8 EPH receptor A8".

[pmid10498895-7] Choi S, Park S (Sep 1999). "Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity". Oncogene. 18 (39): 5413–22. doi:10.1038/sj.onc.1202917. PMID 10498895.

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

EPHA8

Function

Interactions

References

Further reading