Vesicular inhibitory amino acid transporter

SLC32A1
Identifiers
Aliases	SLC32A1, VGAT, VIAAT, solute carrier family 32 member 1
External IDs	OMIM: 616440 MGI: 1194488 HomoloGene: 56451 GeneCards: SLC32A1
Gene location (Human)
Chr.	Chromosome 20 (human)[1]
End	38,729,372 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	158,615,748 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• glycine transmembrane transporter activity; • amino acid transmembrane transporter activity; • gamma-aminobutyric acid:proton symporter activity;
Cellular component	• integral component of membrane; • membrane; • synaptic vesicle; • cell membrane; • clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane; • synapse; • inhibitory synapse; • synaptic vesicle membrane; • presynaptic active zone; • dendrite terminus; • dendrite; • cone cell pedicle; • intracellular organelle; • cell tip; • neuron projection; • neuron projection terminus; • cytoplasmic vesicle membrane; • cytoplasmic vesicle; • integral component of synaptic vesicle membrane; • GABA-ergic synapse;
Biological process	• amino acid transmembrane transport; • aging; • ion transport; • gamma-aminobutyric acid transport; • neurotransmitter transport; • hippocampus development; • neurotransmitter secretion; • glycine transport; • neurotransmitter loading into synaptic vesicle;
	Sources:Amigo / QuickGO
Orthologs
	140679
	22348
	ENSG00000101438
	ENSMUSG00000037771
	Q9H598
	O35633
	NM_080552
	NM_009508
	NP_542119
	NP_033534
	Wikidata
View/Edit Human	View/Edit Mouse

Vesicular inhibitory amino acid transporter is a protein that in humans is encoded by the SLC32A1 gene.[5]

The protein encoded by this gene is an integral membrane protein involved in gamma-aminobutyric acid (GABA) and glycine uptake into synaptic vesicles. The encoded protein is a member of amino acid/polyamine transporter family II.[5]

References

GRCh38: Ensembl release 89: ENSG00000101438 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000037771 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1".

McIntire SL, Reimer RJ, Schuske K, et al. (1997). "Identification and characterization of the vesicular GABA transporter". Nature. 389 (6653): 870–6. doi:10.1038/39908. PMID 9349821.
Kleiderlein JJ, Nisson PE, Jessee J, et al. (1999). "CCG repeats in cDNAs from human brain". Hum. Genet. 103 (6): 666–73. doi:10.1007/s004390050889. PMID 9921901.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Chessler SD, Simonson WT, Sweet IR, Hammerle LP (2002). "Expression of the vesicular inhibitory amino acid transporter in pancreatic islet cells: distribution of the transporter within rat islets". Diabetes. 51 (6): 1763–71. doi:10.2337/diabetes.51.6.1763. PMID 12031963.
Jellali A, Stussi-Garaud C, Gasnier B, et al. (2002). "Cellular localization of the vesicular inhibitory amino acid transporter in the mouse and human retina". J. Comp. Neurol. 449 (1): 76–87. doi:10.1002/cne.10272. PMID 12115694.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Geigerseder C, Doepner R, Thalhammer A, et al. (2003). "Evidence for a GABAergic system in rodent and human testis: local GABA production and GABA receptors". Neuroendocrinology. 77 (5): 314–23. doi:10.1159/000070897. PMID 12806177.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000101438 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037771 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1".

Vesicular inhibitory amino acid transporter

See also

References

Further reading