SLC22A1

SLC22A1
Identifiers
Aliases	SLC22A1, HOCT1, OCT1, oct1_cds, solute carrier family 22 member 1
External IDs	OMIM: 602607 MGI: 108111 HomoloGene: 20665 GeneCards: SLC22A1
Gene location (Human)
Chr.	Chromosome 6 (human)[1]
End	160,158,718 bp[1]
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)[2]
End	12,675,829 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• GO:0005333 norepinephrine:sodium symporter activity; • protein homodimerization activity; • GO:0022891 transmembrane transporter activity; • transporter activity; • acetylcholine transmembrane transporter activity; • dopamine transmembrane transporter activity; • monoamine transmembrane transporter activity; • GO:0001948 protein binding; • identical protein binding; • secondary active organic cation transmembrane transporter activity; • quaternary ammonium group transmembrane transporter activity; • organic cation transmembrane transporter activity; • organic anion transmembrane transporter activity; • dopamine:sodium symporter activity;
Cellular component	• integral component of membrane; • membrane; • cell membrane; • integral component of plasma membrane; • basolateral plasma membrane;
Biological process	• establishment or maintenance of transmembrane electrochemical gradient; • drug transmembrane transport; • quaternary ammonium group transport; • acetate ester transport; • cation transport; • ion transport; • monoamine transport; • norepinephrine transport; • epinephrine transport; • organic cation transport; • dopamine transport; • protein homooligomerization; • ammonium transmembrane transport; • transmembrane transport; • neurotransmitter transport; • organic anion transport; • norepinephrine uptake; • dopamine uptake;
	Sources:Amigo / QuickGO
Orthologs
	6580
	20517
	ENSG00000175003
	ENSMUSG00000023829
	O15245
	O08966
	NM_003057; NM_153187
	NM_009202
	NP_003048; NP_694857
	NP_033228
	Wikidata
View/Edit Human	View/Edit Mouse

Solute carrier family 22 member 1 is a protein that in humans is encoded by the gene SLC22A1.[5][6]

Function

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter.[6]

It is also required for the uptake of metformin by cells.[7][8]

References

GRCh38: Ensembl release 89: ENSG00000175003 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000023829 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Koehler MR, Wissinger B, Gorboulev V, Koepsell H, Schmid M (Jun 1998). "The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26". Cytogenetics and Cell Genetics. 79 (3–4): 198–200. doi:10.1159/000134720. PMID 9605850.
"Entrez Gene: SLC22A1 solute carrier family 22 (organic cation transporter), member 1".
Pryor, R; Cabreiro, F; Haberland, G (16 October 2015). "Repurposing metformin: an old drug with new tricks in its binding pockets". Biochemical Journal. 471 (3): 307–322. doi:10.1042/BJ20150497. PMC 4613459. PMID 26475449.
Rosilio, C; Ben-Sahra, I; Bost, F; Peyron, JF (1 May 2014). "Metformin: a metabolic disruptor and anti-diabetic drug to target human leukemia". Cancer Letters. 346 (2): 188–96. doi:10.1016/j.canlet.2014.01.006. PMID 24462823.

Berkhout B, Jeang KT (January 1992). "Functional roles for the TATA promoter and enhancers in basal and Tat-induced expression of the human immunodeficiency virus type 1 long terminal repeat". Journal of Virology. 66 (1): 139–49. PMC 238269. PMID 1727476.
Jeang KT, Chun R, Lin NH, Gatignol A, Glabe CG, Fan H (October 1993). "In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor". Journal of Virology. 67 (10): 6224–33. PMC 238044. PMID 7690421.
Liu YZ, Lania L, Latchman DS (October 1996). "Functional interaction between the HIV-1 Tat transactivator and the inhibitory domain of the Oct-2 cellular transcription factor". AIDS. 10 (12): 1323–9. doi:10.1097/00002030-199610000-00003. PMID 8902060.
Liu YZ, Latchman DS (February 1997). "The octamer-binding proteins Oct-1 and Oct-2 repress the HIV long terminal repeat promoter and its transactivation by Tat". The Biochemical Journal. 322 (Pt 1): 155–8. doi:10.1042/bj3220155. PMC 1218171. PMID 9078256.
Zhang L, Dresser MJ, Gray AT, Yost SC, Terashita S, Giacomini KM (June 1997). "Cloning and functional expression of a human liver organic cation transporter". Molecular Pharmacology. 51 (6): 913–21. doi:10.1124/mol.51.6.913. PMID 9187257.
Gorboulev V, Ulzheimer JC, Akhoundova A, Ulzheimer-Teuber I, Karbach U, Quester S, Baumann C, Lang F, Busch AE, Koepsell H (July 1997). "Cloning and characterization of two human polyspecific organic cation transporters". DNA and Cell Biology. 16 (7): 871–81. doi:10.1089/dna.1997.16.871. PMID 9260930.
Verhaagh S, Schweifer N, Barlow DP, Zwart R (January 1999). "Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27". Genomics. 55 (2): 209–18. doi:10.1006/geno.1998.5639. PMID 9933568.
Chasman D, Cepek K, Sharp PA, Pabo CO (October 1999). "Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface". Genes & Development. 13 (20): 2650–7. doi:10.1101/gad.13.20.2650. PMC 317104. PMID 10541551.
Tomilin A, Reményi A, Lins K, Bak H, Leidel S, Vriend G, Wilmanns M, Schöler HR (December 2000). "Synergism with the coactivator OBF-1 (OCA-B, BOB-1) is mediated by a specific POU dimer configuration". Cell. 103 (6): 853–64. doi:10.1016/S0092-8674(00)00189-6. PMID 11136971.
Hayer M, Bönisch H, Brüss M (November 1999). "Molecular cloning, functional characterization and genomic organization of four alternatively spliced isoforms of the human organic cation transporter 1 (hOCT1/SLC22A1)". Annals of Human Genetics. 63 (Pt 6): 473–82. doi:10.1046/j.1469-1809.2000.6430267.x. PMID 11388889.
Pietig G, Mehrens T, Hirsch JR, Cetinkaya I, Piechota H, Schlatter E (September 2001). "Properties and regulation of organic cation transport in freshly isolated human proximal tubules". The Journal of Biological Chemistry. 276 (36): 33741–6. doi:10.1074/jbc.M104617200. PMID 11447227.
Pan H, Qin WX, Huo KK, Wan DF, Yu Y, Xu ZG, Hu QD, Gu KT, Zhou XM, Jiang HQ, Zhang PP, Huang Y, Li YY, Gu JR (September 2001). "Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1". Genomics. 77 (1–2): 58–64. doi:10.1006/geno.2001.6614. PMID 11543633.
Xu XR, Huang J, Xu ZG, Qian BZ, Zhu ZD, Yan Q, Cai T, Zhang X, Xiao HS, Qu J, Liu F, Huang QH, Cheng ZH, Li NG, Du JJ, Hu W, Shen KT, Lu G, Fu G, Zhong M, Xu SH, Gu WY, Huang W, Zhao XT, Hu GX, Gu JR, Chen Z, Han ZG (December 2001). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver". Proceedings of the National Academy of Sciences of the United States of America. 98 (26): 15089–94. doi:10.1073/pnas.241522398. PMC 64988. PMID 11752456.
Schinkel AH, Jonker JW (November 2002). "Polymorphisms affecting function of the human organic cation transporter hOCT1 (SLC22A1): what are the consequences?". Pharmacogenetics. 12 (8): 589–90. doi:10.1097/00008571-200211000-00001. PMID 12439217.
Kerb R, Brinkmann U, Chatskaia N, Gorbunov D, Gorboulev V, Mornhinweg E, Keil A, Eichelbaum M, Koepsell H (November 2002). "Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences". Pharmacogenetics. 12 (8): 591–5. doi:10.1097/00008571-200211000-00002. PMID 12439218.
Schaffer A, Kim EC, Wu X, Zan H, Testoni L, Salamon S, Cerutti A, Casali P (June 2003). "Selective inhibition of class switching to IgG and IgE by recruitment of the HoxC4 and Oct-1 homeodomain proteins and Ku70/Ku86 to newly identified ATTT cis-elements". The Journal of Biological Chemistry. 278 (25): 23141–50. doi:10.1074/jbc.M212952200. PMID 12672812.
Shu Y, Leabman MK, Feng B, Mangravite LM, Huang CC, Stryke D, Kawamoto M, Johns SJ, DeYoung J, Carlson E, Ferrin TE, Herskowitz I, Giacomini KM (May 2003). "Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1". Proceedings of the National Academy of Sciences of the United States of America. 100 (10): 5902–7. doi:10.1073/pnas.0730858100. PMC 156299. PMID 12719534.
Sakata T, Anzai N, Shin HJ, Noshiro R, Hirata T, Yokoyama H, Kanai Y, Endou H (January 2004). "Novel single nucleotide polymorphisms of organic cation transporter 1 (SLC22A1) affecting transport functions". Biochemical and Biophysical Research Communications. 313 (3): 789–93. doi:10.1016/j.bbrc.2003.11.175. PMID 14697261.
Bottalico B, Larsson I, Brodszki J, Hernandez-Andrade E, Casslén B, Marsál K, Hansson SR (July 2004). "Norepinephrine transporter (NET), serotonin transporter (SERT), vesicular monoamine transporter (VMAT2) and organic cation transporters (OCT1, 2 and EMT) in human placenta from pre-eclamptic and normotensive pregnancies". Placenta. 25 (6): 518–29. doi:10.1016/j.placenta.2003.10.017. PMID 15135235.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000175003 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023829 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9605850-5] Koehler MR, Wissinger B, Gorboulev V, Koepsell H, Schmid M (Jun 1998). "The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26". Cytogenetics and Cell Genetics. 79 (3–4): 198–200. doi:10.1159/000134720. PMID 9605850.

[entrez-6] "Entrez Gene: SLC22A1 solute carrier family 22 (organic cation transporter), member 1".

[7] Pryor, R; Cabreiro, F; Haberland, G (16 October 2015). "Repurposing metformin: an old drug with new tricks in its binding pockets". Biochemical Journal. 471 (3): 307–322. doi:10.1042/BJ20150497. PMC 4613459. PMID 26475449.

[8] Rosilio, C; Ben-Sahra, I; Bost, F; Peyron, JF (1 May 2014). "Metformin: a metabolic disruptor and anti-diabetic drug to target human leukemia". Cancer Letters. 346 (2): 188–96. doi:10.1016/j.canlet.2014.01.006. PMID 24462823.

SLC22A1

Function

See also

References

Further reading