Monocarboxylate transporter 3

Monocarboxylate transporter 3 (MCT3) also known as solute carrier family 16 member 8 is a protein that in humans is encoded by the SLC16A8 gene.[5] MCT is a proton-coupled monocarboxylate transporter. It catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. It also functions as high-affinity pyruvate transporter.

SLC16A8
Identifiers
AliasesSLC16A8, MCT3, REMP, solute carrier family 16 member 8
External IDsOMIM: 610409 MGI: 1929519 HomoloGene: 75006 GeneCards: SLC16A8
Gene location (Human)
Chr.Chromosome 22 (human)[1]
Band22q13.1Start38,078,134 bp[1]
End38,084,093 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

23539

57274

Ensembl

ENSG00000100156

ENSMUSG00000032988

UniProt

O95907

O35308

RefSeq (mRNA)

NM_013356

NM_020516

RefSeq (protein)

NP_037488

NP_065262

Location (UCSC)Chr 22: 38.08 – 38.08 MbChr 15: 79.25 – 79.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Expression of SLC16A8 is confined to the retinal pigment epithelium and choroid plexus epithelia, where it is located on the basal membrane in contrast to MCT1 which is found on the apical membrane.

See also

References
  1. GRCh38: Ensembl release 89: ENSG00000100156 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000032988 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Garcia CK, Goldstein JL, Pathak RK, Anderson RG, Brown MS (Mar 1994). "Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle". Cell. 76 (5): 865–73. doi:10.1016/0092-8674(94)90361-1. PMID 8124722.

Further reading
  • Yoon H, Donoso LA, Philp NJ (1999). "Cloning of the human monocarboxylate transporter MCT3 gene: localization to chromosome 22q12.3-q13.2". Genomics. 60 (3): 366–70. doi:10.1006/geno.1999.5926. PMID 10493836.
  • Philp NJ, Wang D, Yoon H, Hjelmeland LM (2003). "Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells". Invest. Ophthalmol. Vis. Sci. 44 (4): 1716–21. doi:10.1167/iovs.02-0287. PMID 12657613.
  • Wilson MC, Meredith D, Fox JE, Manoharan C, Davies AJ, Halestrap AP (2005). "Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70)". J. Biol. Chem. 280 (29): 27213–21. doi:10.1074/jbc.M411950200. PMID 15917240.
  • Cori CF (1981). "The glucose-lactic acid cycle and gluconeogenesis". Curr. Top. Cell. Regul. 18: 377–87. PMID 7273846.
  • Halestrap AP, Meredith D (2004). "The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond". Pflügers Arch. 447 (5): 619–28. doi:10.1007/s00424-003-1067-2. PMID 12739169.


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