ADP/ATP translocase 3

SLC25A6
Identifiers
Aliases	SLC25A6, ADP/ATP translocase 3, solute carrier family 25 member 6, AAC3, ANT 2, ANT 3, ANT3, ANT3Y, ANT
External IDs	OMIM: 300151, 403000 HomoloGene: 68194 GeneCards: SLC25A6
Gene location (Human)
Chr.	X chromosome (human)[1]
End	1,392,113 bp[1]
Gene ontology
Molecular function	• transporter activity; • GO:0001948 protein binding; • adenine transmembrane transporter activity; • ATP:ADP antiporter activity; • GO:0022891 transmembrane transporter activity;
Cellular component	• membrane; • TIM23 mitochondrial import inner membrane translocase complex; • mitochondrion; • mitochondrial inner membrane; • cell nucleus; • extracellular matrix; • integral component of membrane;
Biological process	• active induction of host immune response by virus; • regulation of insulin secretion; • protein targeting to mitochondrion; • transmembrane transport; • apoptotic process; • ADP transport; • ATP transport; • viral process; • adenine transport; • regulation of mitochondrial membrane permeability; • transport;
	Sources:Amigo / QuickGO
Orthologs
	293
	n/a
	ENSG00000169100
	n/a
	P12236; Q6I9V5
	n/a
	NM_001636
	n/a
	NP_001627; NP_001627.2
	n/a
	Wikidata
View/Edit Human

ADP/ATP translocase 3, also known as solute carrier family 25 member 6, is a protein that in humans is encoded by the SLC25A6 gene.[3]

Identical copies of this gene reside on the pseudoautosomal regions of the X and Y chromosomes.[4]

References

GRCh38: Ensembl release 89: ENSG00000169100 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Palmieri F (February 2004). "The mitochondrial transporter family (SLC25): physiological and pathological implications". Pflügers Arch. 447 (5): 689–709. doi:10.1007/s00424-003-1099-7. PMID 14598172.
Slim R, Levilliers J, Lüdecke HJ, Claussen U, Nguyen VC, Gough NM, Horsthemke B, Petit C (April 1993). "A human pseudoautosomal gene encodes the ANT3 ADP/ATP translocase and escapes X-inactivation". Genomics. 16 (1): 26–33. doi:10.1006/geno.1993.1135. PMID 8486369.

Jang JY, Lee CE (2003). "Mitochondrial adenine nucleotide translocator 3 is regulated by IL-4 and IFN-gamma via STAT-dependent pathways". Cell. Immunol. 226 (1): 11–9. doi:10.1016/j.cellimm.2003.11.004. PMID 14746803.
Komaki H, Fukazawa T, Houzen H, et al. (2002). "A novel D104G mutation in the adenine nucleotide translocator 1 gene in autosomal dominant progressive external ophthalmoplegia patients with mitochondrial DNA with multiple deletions". Ann. Neurol. 51 (5): 645–8. doi:10.1002/ana.10172. PMID 12112115.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070.
Majima E, Takeda M, Miki S, et al. (2002). "Close location of the first loop to the third loop of the mitochondrial ADP/ATP carrier deduced from cross-linking catalyzed by copper-o-phenanthroline of the solubilized carrier with Triton X-100". J. Biochem. 131 (3): 461–8. doi:10.1093/oxfordjournals.jbchem.a003122. PMID 11872176.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Zamora M, Granell M, Mampel T, Viñas O (2004). "Adenine nucleotide translocase 3 (ANT3) overexpression induces apoptosis in cultured cells". FEBS Lett. 563 (1–3): 155–60. doi:10.1016/S0014-5793(04)00293-5. PMID 15063741.
Hu Z, Guo X, Yu Q, et al. (2009). "Down-regulation of adenine nucleotide translocase 3 and its role in camptothecin-induced apoptosis in human hepatoma QGY7703 cells". FEBS Lett. 583 (2): 383–8. doi:10.1016/j.febslet.2008.12.029. PMID 19111545.
De Marcos Lousa C, Trézéguet V, Dianoux AC, et al. (2002). "The human mitochondrial ADP/ATP carriers: kinetic properties and biogenesis of wild-type and mutant proteins in the yeast S. cerevisiae". Biochemistry. 41 (48): 14412–20. doi:10.1021/bi0261490. PMID 12450408.
Zamora M, Ortega JA, Alaña L, et al. (2006). "Apoptotic and anti-proliferative effects of all-trans retinoic acid. Adenine nucleotide translocase sensitizes HeLa cells to all-trans retinoic acid". Exp. Cell Res. 312 (10): 1813–9. doi:10.1016/j.yexcr.2006.02.014. PMID 16556444.
Yang Z, Cheng W, Hong L, et al. (2007). "Adenine nucleotide (ADP/ATP) translocase 3 participates in the tumor necrosis factor induced apoptosis of MCF-7 cells". Mol. Biol. Cell. 18 (11): 4681–9. doi:10.1091/mbc.E06-12-1161. PMC 2043556. PMID 17855512.
Tu LC, Yan X, Hood L, Lin B (2007). "Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells". Mol. Cell. Proteomics. 6 (4): 575–88. doi:10.1074/mcp.M600249-MCP200. PMID 17220478.
Mühlenbein N, Hofmann S, Rothbauer U, Bauer MF (2004). "Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria". J. Biol. Chem. 279 (14): 13540–6. doi:10.1074/jbc.M312485200. PMID 14726512.
Verrier F, Mignotte B, Jan G, Brenner C (2003). "Study of PTPC composition during apoptosis for identification of viral protein target". Ann. N. Y. Acad. Sci. 1010 (1): 126–42. doi:10.1196/annals.1299.022. PMID 15033708.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Napoli L, Bordoni A, Zeviani M, et al. (2001). "A novel missense adenine nucleotide translocator-1 gene mutation in a Greek adPEO family". Neurology. 57 (12): 2295–8. doi:10.1212/wnl.57.12.2295. PMID 11756613.
Chanturiya AN, Basañez G, Schubert U, et al. (2004). "PB1-F2, an influenza A virus-encoded proapoptotic mitochondrial protein, creates variably sized pores in planar lipid membranes". J. Virol. 78 (12): 6304–12. doi:10.1128/JVI.78.12.6304-6312.2004. PMC 416516. PMID 15163724.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Jang JY, Lee CE (2006). "IL-4-induced upregulation of adenine nucleotide translocase 3 and its role in Th cell survival from apoptosis". Cell. Immunol. 241 (1): 14–25. doi:10.1016/j.cellimm.2006.07.006. PMID 16930576.
Zamarin D, García-Sastre A, Xiao X, et al. (2005). "Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1". PLoS Pathog. 1 (1): e4. doi:10.1371/journal.ppat.0010004. PMC 1238739. PMID 16201016.
Deniaud A, Brenner C, Kroemer G (2004). "Mitochondrial membrane permeabilization by HIV-1 Vpr". Mitochondrion. 4 (2–3): 223–33. doi:10.1016/j.mito.2004.06.012. PMID 16120388.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000169100 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid14598172-3] Palmieri F (February 2004). "The mitochondrial transporter family (SLC25): physiological and pathological implications". Pflügers Arch. 447 (5): 689–709. doi:10.1007/s00424-003-1099-7. PMID 14598172.

[pmid8486369-4] Slim R, Levilliers J, Lüdecke HJ, Claussen U, Nguyen VC, Gough NM, Horsthemke B, Petit C (April 1993). "A human pseudoautosomal gene encodes the ANT3 ADP/ATP translocase and escapes X-inactivation". Genomics. 16 (1): 26–33. doi:10.1006/geno.1993.1135. PMID 8486369.

ADP/ATP translocase 3

See also

References

Further reading