Electroneutral sodium bicarbonate exchanger 1

Electroneutral sodium bicarbonate exchanger 1 is a protein that in humans is encoded by the SLC4A8 gene.[5][6]

SLC4A8
Identifiers
AliasesSLC4A8, NBC3, NDCBE, solute carrier family 4 member 8
External IDsOMIM: 605024 MGI: 1928745 HomoloGene: 68419 GeneCards: SLC4A8
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12q13.13Start51,391,317 bp[1]
End51,515,763 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9498

59033

Ensembl

ENSG00000050438

ENSMUSG00000023032

UniProt

Q2Y0W8

Q8JZR6

RefSeq (mRNA)

NM_001033218
NM_021530
NM_001347102

RefSeq (protein)

NP_001035049
NP_001245330
NP_001245331
NP_001245332
NP_001254544

NP_001334031
NP_067505

Location (UCSC)Chr 12: 51.39 – 51.52 MbChr 15: 100.76 – 100.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

See also

Interactions

SLC4A8 has been shown to interact with Sodium-hydrogen antiporter 3 regulator 1[7][8] and Cystic fibrosis transmembrane conductance regulator.[8]

References
  1. GRCh38: Ensembl release 89: ENSG00000050438 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000023032 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Grichtchenko II, Choi I, Zhong X, Bray-Ward P, Russell JM, Boron WF (May 2001). "Cloning, characterization, and chromosomal mapping of a human electroneutral Na+-driven Cl−HCO3 exchanger". J Biol Chem. 276 (11): 8358–63. doi:10.1074/jbc.C000716200. PMID 11133997.
  6. "Entrez Gene: SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8".
  7. Pushkin A, Abuladze N, Newman D, Muronets V, Sassani P, Tatishchev S, Kurtz I (March 2003). "The COOH termini of NBC3 and the 56-kDa H+-ATPase subunit are PDZ motifs involved in their interaction". Am. J. Physiol., Cell Physiol. 284 (3): C667–73. doi:10.1152/ajpcell.00225.2002. PMID 12444018.
  8. Park M, Ko SB, Choi JY, Muallem G, Thomas PJ, Pushkin A, Lee MS, Kim JY, Lee MG, Muallem S, Kurtz I (December 2002). "The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3− salvage transporter human Na+-HCO3− cotransport isoform 3". J. Biol. Chem. 277 (52): 50503–9. doi:10.1074/jbc.M201862200. PMID 12403779.

Further reading
  • Soleimani M (2002). "Na+:HCO3− cs (NBC): expression and regulation in the kidney". J. Nephrol. 15 Suppl 5: S32–40. PMID 12027220.
  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Loiselle FB, Morgan PE, Alvarez BV, Casey JR (2004). "Regulation of the human NBC3 Na+/HCO3− cotransporter by carbonic anhydrase II and PKA". Am. J. Physiol., Cell Physiol. 286 (6): C1423–33. doi:10.1152/ajpcell.00382.2003. PMID 14736710.
  • Pushkin A, Abuladze N, Newman D, Muronets V, Sassani P, Tatishchev S, Kurtz I (2003). "The COOH termini of NBC3 and the 56-kDa H+-ATPase subunit are PDZ motifs involved in their interaction". Am. J. Physiol., Cell Physiol. 284 (3): C667–73. doi:10.1152/ajpcell.00225.2002. PMID 12444018.
  • Park M, Ko SB, Choi JY, Muallem G, Thomas PJ, Pushkin A, Lee MS, Kim JY, Lee MG, Muallem S, Kurtz I (2003). "The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3− salvage transporter human Na+-HCO3− cotransport isoform 3". J. Biol. Chem. 277 (52): 50503–9. doi:10.1074/jbc.M201862200. PMID 12403779.
  • Gresz V, Kwon TH, Vorum H, Zelles T, Kurtz I, Steward MC, Aalkjaer C, Nielsen S (2002). "Immunolocalization of electroneutral Na+-HCO cotransporters in human and rat salivary glands". Am. J. Physiol. Gastrointest. Liver Physiol. 283 (2): G473–80. doi:10.1152/ajpgi.00421.2001. PMID 12121896.
  • Amlal H, Burnham CE, Soleimani M (1999). "Characterization of Na+/HCO3− cotransporter isoform NBC-3". Am. J. Physiol. 276 (6 Pt 2): F903–13. PMID 10362779.
  • Pushkin A, Abuladze N, Lee I, Newman D, Hwang J, Kurtz I (1999). "Cloning, tissue distribution, genomic organization, and functional characterization of NBC3, a new member of the sodium bicarbonate cotransporter family". J. Biol. Chem. 274 (23): 16569–75. doi:10.1074/jbc.274.23.16569. PMID 10347222.
  • Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.


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