Tropomodulin

Tropomodulin (TMOD) is a protein which binds and caps the minus end of actin (the "pointed" end), regulating the length of actin filaments in muscle and non-muscle cells.[1] The protein functions by physically blocking the spontaneous dissociation of ADP-bound actin monomers from the minus end of the actin fibre. This, along with plus end capping proteins, such as capZ stabilise the structure of the actin filament. End capping is particularly important when long-lived actin filaments are necessary, for example: in myofibrils. Inhibition of tropomodulin capping activity leads to dramatic increase in thin filament length from its pointed end.[2][3]

Genes

References
  1. Rao, J. N.; Madasu, Y.; Dominguez, R. (24 July 2014). "Mechanism of actin filament pointed-end capping by tropomodulin". Science. 345 (6195): 463–467. doi:10.1126/science.1256159. PMC 4367809. PMID 25061212.
  2. Requirement of pointed-end capping by tropomodulin to maintain actin filament length in embryonic, retrieved 2009-04-10
  3. Gunning PW, Ghoshdastider U, Whitaker S, Popp D, Robinson RC (2015). "The evolution of compositionally and functionally distinct actin filaments". Journal of Cell Science. 128 (11): 2009–19. doi:10.1242/jcs.165563. PMID 25788699.


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