MYO1C

Myosin-Ic is a protein that in humans is encoded by the MYO1C gene.[4][5]

MYO1C
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMYO1C, MMI-beta, MMIb, NMI, myr2, myosin IC
External IDsOMIM: 606538 MGI: 106612 HomoloGene: 32046 GeneCards: MYO1C
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17p13.3Start1,464,186 bp[1]
End1,492,686 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

4641

17913

Ensembl

ENSG00000197879

n/a

UniProt

O00159

Q9WTI7

RefSeq (mRNA)

NM_033375
NM_001080779
NM_001080950
NM_001363855

NM_001080774
NM_001080775
NM_008659
NM_001370611

RefSeq (protein)

NP_001074248
NP_001074419
NP_203693
NP_001350784

NP_001074243
NP_001074244
NP_032685
NP_001357540

Location (UCSC)Chr 17: 1.46 – 1.49 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. The mouse ortholog of this protein also functions in intracellular vesicle transport to the plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. The related gene myosin IE has been referred to as myosin IC in the literature, but it is a distinct locus on chromosome 19.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000197879 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Crozet F, el Amraoui A, Blanchard S, Lenoir M, Ripoll C, Vago P, Hamel C, Fizames C, Levi-Acobas F, Depetris D, Mattei MG, Weil D, Pujol R, Petit C (Apr 1997). "Cloning of the genes encoding two murine and human cochlear unconventional type I myosins". Genomics. 40 (2): 332–41. doi:10.1006/geno.1996.4526. PMID 9119401.
  5. "Entrez Gene: MYO1C myosin IC".

Further reading

  • Overview of all the structural information available in the PDB for UniProt: O00159 (Unconventional myosin-Ic) at the PDBe-KB.
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