KIFC1
Kinesin-like protein KIFC1 is a protein that in humans is encoded by the KIFC1 gene.[5][6]
Function
The protein KifC1 is a member of kinesin-14 family. KifC1 consists of C-terminal motor domain, superhelical stalk and N-terminal tail domain. Tail and motor domains contain microtubule-binding sites. This kinesin moves towards the minus-end of microtubule and has an ability to slide or crosslink microtubules. KifC1 functions during mitotic spindle formation.
References
- ENSG00000204197, ENSG00000237649, ENSG00000056678 GRCh38: Ensembl release 89: ENSG00000233450, ENSG00000204197, ENSG00000237649, ENSG00000056678 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000024301 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Ando A, Kikuti YY, Kawata H, Okamoto N, Imai T, Eki T, Yokoyama K, Soeda E, Ikemura T, Abe K (Feb 1994). "Cloning of a new kinesin-related gene located at the centromeric end of the human MHC region". Immunogenetics. 39 (3): 194–200. doi:10.1007/bf00241260. PMID 8276466.
- "Entrez Gene: KIFC1 kinesin family member C1".
Further reading
- Miki H, Setou M, Kaneshiro K, Hirokawa N (2001). "All kinesin superfamily protein, KIF, genes in mouse and human". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7004–7011. doi:10.1073/pnas.111145398. PMC 34614. PMID 11416179.
- Janitz K, Wild A, Beck S, Savasta S, Beluffi G, Ziegler A, Volz A (1999). "Genomic organization of the HSET locus and the possible association of HLA-linked genes with immotile cilia syndrome (ICS)". Immunogenetics. 49 (7–8): 644–652. doi:10.1007/s002510050660. PMID 10369922.
- Neef R, Preisinger C, Sutcliffe J, Kopajtich R, Nigg EA, Mayer TU, Barr FA (2003). "Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis" (PDF). J. Cell Biol. 162 (5): 863–875. doi:10.1083/jcb.200306009. PMC 2172827. PMID 12939256.
- Gruneberg U, Neef R, Honda R, Nigg EA, Barr FA (2004). "Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2". J. Cell Biol. 166 (2): 167–172. doi:10.1083/jcb.200403084. PMC 2172317. PMID 15263015.
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Al-Bassam J, Roger B, Halpain S, Milligan RA (2007). "Analysis of the weak interactions of ADP-Unc104 and ADP-kinesin with microtubules and their inhibition by MAP2c". Cell Motil. Cytoskeleton. 64 (5): 377–389. doi:10.1002/cm.20190. PMID 17326138.
External links
- Overview of all the structural information available in the PDB for UniProt: Q9BW19 (Human Kinesin-like protein KIFC1) at the PDBe-KB.
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