MYO18B

Myosin-XVIIIb is a protein that in humans is encoded by the MYO18B gene.[5][6][7]

MYO18B
Identifiers
AliasesMYO18B, KFS4, myosin XVIIIB
External IDsOMIM: 607295 MGI: 1921626 HomoloGene: 53435 GeneCards: MYO18B
Gene location (Human)
Chr.Chromosome 22 (human)[1]
Band22q12.1Start25,742,144 bp[1]
End26,031,041 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

84700

74376

Ensembl

ENSG00000133454

ENSMUSG00000072720

UniProt

Q8IUG5

n/a

RefSeq (mRNA)

NM_032608
NM_001318245

NM_028901

RefSeq (protein)

NP_001305174
NP_115997

n/a

Location (UCSC)Chr 22: 25.74 – 26.03 MbChr 5: 112.69 – 112.9 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact with F actin. Mutations in this gene are associated with lung cancer.[7]

References
  1. GRCh38: Ensembl release 89: ENSG00000133454 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000072720 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nishioka M, Kohno T, Tani M, Yanaihara N, Tomizawa Y, Otsuka A, Sasaki S, Kobayashi K, Niki T, Maeshima A, Sekido Y, Minna JD, Sone S, Yokota J (Sep 2002). "MYO18B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer". Proc Natl Acad Sci U S A. 99 (19): 12269–74. doi:10.1073/pnas.192445899. PMC 129434. PMID 12209013.
  6. Salamon M, Millino C, Raffaello A, Mongillo M, Sandri C, Bean C, Negrisolo E, Pallavicini A, Valle G, Zaccolo M, Schiaffino S, Lanfranchi G (Jan 2003). "Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation". J Mol Biol. 326 (1): 137–49. doi:10.1016/S0022-2836(02)01335-9. PMID 12547197.
  7. "Entrez Gene: MYO18B myosin XVIIIB".

Further reading
  • Yokota J, Nishioka M, Tani M, Kohno T (2003). "Genetic alterations responsible for metastatic phenotypes of lung cancer cells". Clin. Exp. Metastasis. 20 (3): 189–93. doi:10.1023/A:1022978932215. PMID 12741677.
  • Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Yanaihara N, Nishioka M, Kohno T, et al. (2004). "Reduced expression of MYO18B, a candidate tumor-suppressor gene on chromosome arm 22q, in ovarian cancer". Int. J. Cancer. 112 (1): 150–4. doi:10.1002/ijc.20339. PMID 15305387.
  • Inoue T, Kon T, Ajima R, et al. (2006). "MYO18B interacts with the proteasomal subunit Sug1 and is degraded by the ubiquitin-proteasome pathway". Biochem. Biophys. Res. Commun. 342 (3): 829–34. doi:10.1016/j.bbrc.2006.02.025. PMID 16499872.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
  • Edakuni N, Ikuta K, Yano S, et al. (2007). "Restored expression of the MYO18B gene suppresses orthotopic growth and the production of bloody pleural effusion by human malignant pleural mesothelioma cells in SCID mice". Oncol. Res. 16 (5): 235–43. PMID 17294804.


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